Global DNA Hypermethylation in Down Syndrome Placenta

• Main Authors: Jin S., Lee Y.K., Lim Y.C., Zheng Z., Lin X.M., Ng D.P.Y., Holbrook J.D., Law H.Y., Kwek K.Y.C., Yeo G.S.H., Ding C.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: adult; article; chorion villus; chromosome 21; clinical article; controlled study; DNA methylation; down regulation; Down syndrome; epigenetics; female; fetus; gene; gene location; human; human cell; human tissue; male; multigene family; NRSF gene; phenotype; placenta; promoter region; REST gene; tet gene; transcription regulation; upregulation; Chromosomes, Human, Pair 21; CpG Islands; DNA Methylation; DNA-Binding Proteins; Down Syndrome; Epigenesis, Genetic; Female; Gene Expression Regulation; Humans; Male; Placenta; Pregnancy; Promoter Regions, Genetic; Proto-Oncogene Proteins; Repressor Proteins; Sequence Analysis, DNA
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161621
• Institution: National University of Singapore

10.1371/journal.pgen.1003515