Genome-wide association and functional follow-up reveals new loci for kidney function

• Main Authors: Pattaro C., Köttgen A., Teumer A., Garnaas M., Böger C.A., Fuchsberger C., Olden M., Chen M.-H., Tin A., Taliun D., Li M., Gao X., Gorski M., Yang Q., Hundertmark C., Foster M.C., O'Seaghdha C.M., Glazer N., Isaacs A., Liu C.-T., Smith A.V., O'Connell J.R., Struchalin M., Tanaka T., Li G., Johnson A.D., Gierman H.J., Feitosa M., Hwang S.-J., Atkinson E.J., Lohman K., Cornelis M.C., Johansson A., Tönjes A., Dehghan A., Chouraki V., Holliday E.G., Sorice R., Kutalik Z., Lehtimäki T., Esko T., Deshmukh H., Ulivi S., Chu A.Y., Murgia F., Trompet S., Imboden M., Kollerits B., Pistis G., Harris T.B., Launer L.J., Aspelund T., Eiriksdottir G., Mitchell B.D., Boerwinkle E., Schmidt H., Cavalieri M., Rao M., Hu F.B., Demirkan A., Oostra B.A., de Andrade M., Turner S.T., Ding J., Andrews J.S., Freedman B.I., Koenig W., Illig T., Döring A., Wichmann H.-E., Kolcic I., Zemunik T., Boban M., Minelli C., Wheeler H.E., Igl W., Zaboli G., Wild S.H., Wright A.F., Campbell H., Ellinghaus D., Nöthlings U., Jacobs G., Biffar R., Endlich K., Ernst F., Homuth G., Kroemer H.K., Nauck M., Stracke S., Völker U., Völzke H., Kovacs P., Stumvoll M., Mägi R., Hofman A., Uitterlinden A.G., Rivadeneira F., Aulchenko Y.S., Polasek O., Hastie N., Vitart V., Helmer C., Wang J.J., Ruggiero D., Bergmann S., Kähönen M., Viikari J., Nikopensius T., Province M., Ketkar S., Colhoun H., Doney A., Robino A., Giulianini F., Krämer B.K., Portas L., Ford I., Buckley B.M., Adam M., Thun G.-A., Paulweber B., Haun M., Sala C., Metzger M., Mitchell P., Ciullo M., Kim S.K., Vollenweider P., Raitakari O., Metspalu A., Palmer C., Gasparini P., Pirastu M., Jukema J.W., Probst-Hensch N.M., Kronenberg F., Toniolo D., Gudnason V., Shuldiner A.R., Coresh J., Schmidt R., Ferrucci L., Siscovick D.S., van Duijn C.M., Borecki I., Kardia S.L.R., Liu Y., Curhan G.C., Rudan I., Gyllensten U., Wilson J.F., Franke A., Pramstaller P.P., Rettig R., Prokopenko I., Witteman J.C.M., Hayward C., Ridker P., Parsa A., Bochud M., Heid I.M., Goessling W., Chasman D.I., Kao W.H.L., Fox C.S.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: dextran; CASP9 protein, human; caspase 9; CDK12 protein, human; cyclin dependent kinase; DDX1 protein, human; DEAD box protein; helicase; INO80 protein, human; MPPED2 protein, human; phosphodiesterase; African American; article; CASP9 gene; Cdk1 gene; chronic kidney disease; controlled study; DDX1 gene; embryo; ethnic group; European; gene; gene function; gene locus; genetic association; genome analysis; glomerulus filtration rate; human; INO80 gene; kidney clearance; kidney function; MPPED2 gene; nonhuman; podocyte; risk assessment; risk factor; single nucleotide polymorphism; SLC47A1 gene; zebra fish; aged; animal; Caucasian; chronic kidney failure; female; follow up; gene silencing; genetics; kidney; male; meta analysis; middle aged; pathology; pathophysiology; Danio rerio; African Americans; Aged; Animals; Caspase 9; Cyclin-Dependent Kinases; DEAD-box RNA Helicases; DNA Helicases; European Continental Ancestry Group; Female; Follow-Up Studies; Gene Knockdown Techniques; Genome-Wide Association Study; Glomerular Filtration Rate; Humans; Kidney; Kidney Failure, Chronic; Male; Middle Aged; Phosphoric Diester Hydrolases; Zebrafish
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161642
• Institution: National University of Singapore

10.1371/journal.pgen.1002584