Multi-variant pathway association analysis reveals the importance of genetic determinants of estrogen metabolism in breast and endometrial cancer susceptibility

10.1371/journal.pgen.1001012

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Main Authors:	Low Y.L., Li Y., Humphreys K., Thalamuthu A., Darabi H., Wedrén S., Bonnard C., Czene K., Iles M.M., Heikkinen T., Aittomäki K., Blomqvist C., Nevanlinna H., Hall P., Liu E.T., Liu J.
Other Authors:	SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
Format:	Article
Published:	2019
Subjects:	androgen aromatase estrogen estrogen receptor glucuronosyltransferase glucuronosyltransferase 2b4 unclassified drug adult aged androgen synthesis article breast cancer cancer susceptibility carcinogenesis controlled study endometrium cancer estrogen metabolism female Finland gene function genetic association genetic variability human human cell human tissue major clinical study maximum likelihood method multivariate analysis postmenopause single nucleotide polymorphism Sweden analysis of variance breast tumor case control study Caucasian cohort analysis endometrium tumor genetic predisposition genetics metabolism middle aged tumor cell line Aged Analysis of Variance Androgens Breast Neoplasms Case-Control Studies Cell Line, Tumor Cohort Studies Endometrial Neoplasms Estrogens European Continental Ancestry Group Female Genetic Predisposition to Disease Humans Middle Aged Polymorphism, Single Nucleotide Receptors, Estrogen
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161661
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1616612024-04-24T05:54:17Z Multi-variant pathway association analysis reveals the importance of genetic determinants of estrogen metabolism in breast and endometrial cancer susceptibility Low Y.L. Li Y. Humphreys K. Thalamuthu A. Li Y. Darabi H. Wedrén S. Bonnard C. Czene K. Iles M.M. Heikkinen T. Aittomäki K. Blomqvist C. Nevanlinna H. Hall P. Liu E.T. Liu J. SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH MEDICINE androgen aromatase estrogen estrogen receptor glucuronosyltransferase glucuronosyltransferase 2b4 unclassified drug androgen estrogen estrogen receptor adult aged androgen synthesis article breast cancer cancer susceptibility carcinogenesis controlled study endometrium cancer estrogen metabolism female Finland gene function genetic association genetic variability human human cell human tissue major clinical study maximum likelihood method multivariate analysis postmenopause single nucleotide polymorphism Sweden analysis of variance breast tumor case control study Caucasian cohort analysis endometrium tumor genetic predisposition genetics metabolism middle aged tumor cell line Aged Analysis of Variance Androgens Breast Neoplasms Case-Control Studies Cell Line, Tumor Cohort Studies Endometrial Neoplasms Estrogens European Continental Ancestry Group Female Genetic Predisposition to Disease Humans Middle Aged Polymorphism, Single Nucleotide Receptors, Estrogen 10.1371/journal.pgen.1001012 PLoS Genetics 6 7 1-Aug 2019-11-06T09:33:24Z 2019-11-06T09:33:24Z 2010 Article Low Y.L., Li Y., Humphreys K., Thalamuthu A., Li Y., Darabi H., Wedrén S., Bonnard C., Czene K., Iles M.M., Heikkinen T., Aittomäki K., Blomqvist C., Nevanlinna H., Hall P., Liu E.T., Liu J. (2010). Multi-variant pathway association analysis reveals the importance of genetic determinants of estrogen metabolism in breast and endometrial cancer susceptibility. PLoS Genetics 6 (7) : 1-Aug. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pgen.1001012 15537390 https://scholarbank.nus.edu.sg/handle/10635/161661 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	androgen aromatase estrogen estrogen receptor glucuronosyltransferase glucuronosyltransferase 2b4 unclassified drug androgen estrogen estrogen receptor adult aged androgen synthesis article breast cancer cancer susceptibility carcinogenesis controlled study endometrium cancer estrogen metabolism female Finland gene function genetic association genetic variability human human cell human tissue major clinical study maximum likelihood method multivariate analysis postmenopause single nucleotide polymorphism Sweden analysis of variance breast tumor case control study Caucasian cohort analysis endometrium tumor genetic predisposition genetics metabolism middle aged tumor cell line Aged Analysis of Variance Androgens Breast Neoplasms Case-Control Studies Cell Line, Tumor Cohort Studies Endometrial Neoplasms Estrogens European Continental Ancestry Group Female Genetic Predisposition to Disease Humans Middle Aged Polymorphism, Single Nucleotide Receptors, Estrogen
spellingShingle	androgen aromatase estrogen estrogen receptor glucuronosyltransferase glucuronosyltransferase 2b4 unclassified drug androgen estrogen estrogen receptor adult aged androgen synthesis article breast cancer cancer susceptibility carcinogenesis controlled study endometrium cancer estrogen metabolism female Finland gene function genetic association genetic variability human human cell human tissue major clinical study maximum likelihood method multivariate analysis postmenopause single nucleotide polymorphism Sweden analysis of variance breast tumor case control study Caucasian cohort analysis endometrium tumor genetic predisposition genetics metabolism middle aged tumor cell line Aged Analysis of Variance Androgens Breast Neoplasms Case-Control Studies Cell Line, Tumor Cohort Studies Endometrial Neoplasms Estrogens European Continental Ancestry Group Female Genetic Predisposition to Disease Humans Middle Aged Polymorphism, Single Nucleotide Receptors, Estrogen Low Y.L. Li Y. Humphreys K. Thalamuthu A. Li Y. Darabi H. Wedrén S. Bonnard C. Czene K. Iles M.M. Heikkinen T. Aittomäki K. Blomqvist C. Nevanlinna H. Hall P. Liu E.T. Liu J. Multi-variant pathway association analysis reveals the importance of genetic determinants of estrogen metabolism in breast and endometrial cancer susceptibility
description	10.1371/journal.pgen.1001012
author2	SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
author_facet	SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH Low Y.L. Li Y. Humphreys K. Thalamuthu A. Li Y. Darabi H. Wedrén S. Bonnard C. Czene K. Iles M.M. Heikkinen T. Aittomäki K. Blomqvist C. Nevanlinna H. Hall P. Liu E.T. Liu J.
format	Article
author	Low Y.L. Li Y. Humphreys K. Thalamuthu A. Li Y. Darabi H. Wedrén S. Bonnard C. Czene K. Iles M.M. Heikkinen T. Aittomäki K. Blomqvist C. Nevanlinna H. Hall P. Liu E.T. Liu J.
author_sort	Low Y.L.
title	Multi-variant pathway association analysis reveals the importance of genetic determinants of estrogen metabolism in breast and endometrial cancer susceptibility
title_short	Multi-variant pathway association analysis reveals the importance of genetic determinants of estrogen metabolism in breast and endometrial cancer susceptibility
title_full	Multi-variant pathway association analysis reveals the importance of genetic determinants of estrogen metabolism in breast and endometrial cancer susceptibility
title_fullStr	Multi-variant pathway association analysis reveals the importance of genetic determinants of estrogen metabolism in breast and endometrial cancer susceptibility
title_full_unstemmed	Multi-variant pathway association analysis reveals the importance of genetic determinants of estrogen metabolism in breast and endometrial cancer susceptibility
title_sort	multi-variant pathway association analysis reveals the importance of genetic determinants of estrogen metabolism in breast and endometrial cancer susceptibility
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161661
_version_	1800913805212909568

Multi-variant pathway association analysis reveals the importance of genetic determinants of estrogen metabolism in breast and endometrial cancer susceptibility

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