Multi-variant pathway association analysis reveals the importance of genetic determinants of estrogen metabolism in breast and endometrial cancer susceptibility

• Main Authors: Low Y.L., Li Y., Humphreys K., Thalamuthu A., Darabi H., Wedrén S., Bonnard C., Czene K., Iles M.M., Heikkinen T., Aittomäki K., Blomqvist C., Nevanlinna H., Hall P., Liu E.T., Liu J.
• Other Authors: SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
• Format: Article
• Published: 2019
• Subjects: androgen; aromatase; estrogen; estrogen receptor; glucuronosyltransferase; glucuronosyltransferase 2b4; unclassified drug; adult; aged; androgen synthesis; article; breast cancer; cancer susceptibility; carcinogenesis; controlled study; endometrium cancer; estrogen metabolism; female; Finland; gene function; genetic association; genetic variability; human; human cell; human tissue; major clinical study; maximum likelihood method; multivariate analysis; postmenopause; single nucleotide polymorphism; Sweden; analysis of variance; breast tumor; case control study; Caucasian; cohort analysis; endometrium tumor; genetic predisposition; genetics; metabolism; middle aged; tumor cell line; Aged; Analysis of Variance; Androgens; Breast Neoplasms; Case-Control Studies; Cell Line, Tumor; Cohort Studies; Endometrial Neoplasms; Estrogens; European Continental Ancestry Group; Female; Genetic Predisposition to Disease; Humans; Middle Aged; Polymorphism, Single Nucleotide; Receptors, Estrogen
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161661
• Institution: National University of Singapore

10.1371/journal.pgen.1001012