EPHA2 is associated with age-related cortical cataract in mice and humans

10.1371/journal.pgen.1000584

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Main Authors:	Jun G., Guo H., Klein B.E.K., Klein R., Jie J.W., Mitchell P., Miao H., Lee K.E., Joshi T., Buck M., Chugha P., Bardenstein D., Klein A.P., Bailey-Wilson J.E., Gong X., Spector T.D., Andrew T., Hammond C.J., Elston R.C., Iyengar S.K., Wang B.
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	2019
Subjects:	arginine ephrin receptor A2 glutamine heat shock protein 25 heat shock protein 27 protein kinase adult age distribution aged aging amino acid substitution animal model article cataract Caucasian cell differentiation cell stress cell vacuole chemical analysis chromosome 1p controlled study disease course disease duration epithelium cell exon female gene deletion gene frequency gene overexpression genetic association genetic linkage genetic variability human illumination lens lens fiber major clinical study male missense mutation mouse nonhuman population based case control study protein expression protein folding protein function protein phosphorylation receptor upregulation retina macula age related degeneration retroillumination single nucleotide polymorphism visual cortex age animal C57BL mouse chemistry chromosome 1 cohort analysis disease model genetics meta analysis metabolism middle aged molecular genetics mouse mutant mutation pathology protein tertiary structure sequence alignment Murinae Mus Age Factors Aged Animals Cataract Chromosomes, Human, Pair 1 Cohort Studies Disease Models, Animal European Continental Ancestry Group Female Humans Lens, Crystalline Male Mice Mice, Inbred C57BL Mice, Knockout Middle Aged Molecular Sequence Data Mutation Polymorphism, Single Nucleotide Protein Structure, Tertiary Receptor, EphA2 Sequence Alignment Visual Cortex
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161673
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1616732024-11-09T06:38:29Z EPHA2 is associated with age-related cortical cataract in mice and humans Jun G. Guo H. Klein B.E.K. Klein R. Jie J.W. Mitchell P. Miao H. Lee K.E. Joshi T. Buck M. Chugha P. Bardenstein D. Klein A.P. Bailey-Wilson J.E. Gong X. Spector T.D. Andrew T. Hammond C.J. Elston R.C. Iyengar S.K. Wang B. DUKE-NUS MEDICAL SCHOOL arginine ephrin receptor A2 glutamine heat shock protein 25 heat shock protein 27 protein kinase ephrin receptor A2 adult age distribution aged aging amino acid substitution animal model article cataract Caucasian cell differentiation cell stress cell vacuole chemical analysis chromosome 1p controlled study disease course disease duration epithelium cell exon female gene deletion gene frequency gene overexpression genetic association genetic linkage genetic variability human illumination lens lens fiber major clinical study male missense mutation mouse nonhuman population based case control study protein expression protein folding protein function protein phosphorylation receptor upregulation retina macula age related degeneration retroillumination single nucleotide polymorphism visual cortex age animal C57BL mouse cataract chemistry chromosome 1 cohort analysis disease model genetics meta analysis metabolism middle aged molecular genetics mouse mutant mutation pathology protein tertiary structure sequence alignment Murinae Mus Age Factors Aged Animals Cataract Chromosomes, Human, Pair 1 Cohort Studies Disease Models, Animal European Continental Ancestry Group Female Humans Lens, Crystalline Male Mice Mice, Inbred C57BL Mice, Knockout Middle Aged Molecular Sequence Data Mutation Polymorphism, Single Nucleotide Protein Structure, Tertiary Receptor, EphA2 Sequence Alignment Visual Cortex 10.1371/journal.pgen.1000584 PLoS Genetics 5 7 e1000584 2019-11-06T09:35:37Z 2019-11-06T09:35:37Z 2009 Article Jun G., Guo H., Klein B.E.K., Klein R., Jie J.W., Mitchell P., Miao H., Lee K.E., Joshi T., Buck M., Chugha P., Bardenstein D., Klein A.P., Bailey-Wilson J.E., Gong X., Spector T.D., Andrew T., Hammond C.J., Elston R.C., Iyengar S.K., Wang B. (2009). EPHA2 is associated with age-related cortical cataract in mice and humans. PLoS Genetics 5 (7) : e1000584. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pgen.1000584 15537390 https://scholarbank.nus.edu.sg/handle/10635/161673 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	arginine ephrin receptor A2 glutamine heat shock protein 25 heat shock protein 27 protein kinase ephrin receptor A2 adult age distribution aged aging amino acid substitution animal model article cataract Caucasian cell differentiation cell stress cell vacuole chemical analysis chromosome 1p controlled study disease course disease duration epithelium cell exon female gene deletion gene frequency gene overexpression genetic association genetic linkage genetic variability human illumination lens lens fiber major clinical study male missense mutation mouse nonhuman population based case control study protein expression protein folding protein function protein phosphorylation receptor upregulation retina macula age related degeneration retroillumination single nucleotide polymorphism visual cortex age animal C57BL mouse cataract chemistry chromosome 1 cohort analysis disease model genetics meta analysis metabolism middle aged molecular genetics mouse mutant mutation pathology protein tertiary structure sequence alignment Murinae Mus Age Factors Aged Animals Cataract Chromosomes, Human, Pair 1 Cohort Studies Disease Models, Animal European Continental Ancestry Group Female Humans Lens, Crystalline Male Mice Mice, Inbred C57BL Mice, Knockout Middle Aged Molecular Sequence Data Mutation Polymorphism, Single Nucleotide Protein Structure, Tertiary Receptor, EphA2 Sequence Alignment Visual Cortex
spellingShingle	arginine ephrin receptor A2 glutamine heat shock protein 25 heat shock protein 27 protein kinase ephrin receptor A2 adult age distribution aged aging amino acid substitution animal model article cataract Caucasian cell differentiation cell stress cell vacuole chemical analysis chromosome 1p controlled study disease course disease duration epithelium cell exon female gene deletion gene frequency gene overexpression genetic association genetic linkage genetic variability human illumination lens lens fiber major clinical study male missense mutation mouse nonhuman population based case control study protein expression protein folding protein function protein phosphorylation receptor upregulation retina macula age related degeneration retroillumination single nucleotide polymorphism visual cortex age animal C57BL mouse cataract chemistry chromosome 1 cohort analysis disease model genetics meta analysis metabolism middle aged molecular genetics mouse mutant mutation pathology protein tertiary structure sequence alignment Murinae Mus Age Factors Aged Animals Cataract Chromosomes, Human, Pair 1 Cohort Studies Disease Models, Animal European Continental Ancestry Group Female Humans Lens, Crystalline Male Mice Mice, Inbred C57BL Mice, Knockout Middle Aged Molecular Sequence Data Mutation Polymorphism, Single Nucleotide Protein Structure, Tertiary Receptor, EphA2 Sequence Alignment Visual Cortex Jun G. Guo H. Klein B.E.K. Klein R. Jie J.W. Mitchell P. Miao H. Lee K.E. Joshi T. Buck M. Chugha P. Bardenstein D. Klein A.P. Bailey-Wilson J.E. Gong X. Spector T.D. Andrew T. Hammond C.J. Elston R.C. Iyengar S.K. Wang B. EPHA2 is associated with age-related cortical cataract in mice and humans
description	10.1371/journal.pgen.1000584
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Jun G. Guo H. Klein B.E.K. Klein R. Jie J.W. Mitchell P. Miao H. Lee K.E. Joshi T. Buck M. Chugha P. Bardenstein D. Klein A.P. Bailey-Wilson J.E. Gong X. Spector T.D. Andrew T. Hammond C.J. Elston R.C. Iyengar S.K. Wang B.
format	Article
author	Jun G. Guo H. Klein B.E.K. Klein R. Jie J.W. Mitchell P. Miao H. Lee K.E. Joshi T. Buck M. Chugha P. Bardenstein D. Klein A.P. Bailey-Wilson J.E. Gong X. Spector T.D. Andrew T. Hammond C.J. Elston R.C. Iyengar S.K. Wang B.
author_sort	Jun G.
title	EPHA2 is associated with age-related cortical cataract in mice and humans
title_short	EPHA2 is associated with age-related cortical cataract in mice and humans
title_full	EPHA2 is associated with age-related cortical cataract in mice and humans
title_fullStr	EPHA2 is associated with age-related cortical cataract in mice and humans
title_full_unstemmed	EPHA2 is associated with age-related cortical cataract in mice and humans
title_sort	epha2 is associated with age-related cortical cataract in mice and humans
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161673
_version_	1821231650339553280

EPHA2 is associated with age-related cortical cataract in mice and humans

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