EPHA2 is associated with age-related cortical cataract in mice and humans

• Main Authors: Jun G., Guo H., Klein B.E.K., Klein R., Jie J.W., Mitchell P., Miao H., Lee K.E., Joshi T., Buck M., Chugha P., Bardenstein D., Klein A.P., Bailey-Wilson J.E., Gong X., Spector T.D., Andrew T., Hammond C.J., Elston R.C., Iyengar S.K., Wang B.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: arginine; ephrin receptor A2; glutamine; heat shock protein 25; heat shock protein 27; protein kinase; adult; age distribution; aged; aging; amino acid substitution; animal model; article; cataract; Caucasian; cell differentiation; cell stress; cell vacuole; chemical analysis; chromosome 1p; controlled study; disease course; disease duration; epithelium cell; exon; female; gene deletion; gene frequency; gene overexpression; genetic association; genetic linkage; genetic variability; human; illumination; lens; lens fiber; major clinical study; male; missense mutation; mouse; nonhuman; population based case control study; protein expression; protein folding; protein function; protein phosphorylation; receptor upregulation; retina macula age related degeneration; retroillumination; single nucleotide polymorphism; visual cortex; age; animal; C57BL mouse; chemistry; chromosome 1; cohort analysis; disease model; genetics; meta analysis; metabolism; middle aged; molecular genetics; mouse mutant; mutation; pathology; protein tertiary structure; sequence alignment; Murinae; Mus; Age Factors; Aged; Animals; Cataract; Chromosomes, Human, Pair 1; Cohort Studies; Disease Models, Animal; European Continental Ancestry Group; Female; Humans; Lens, Crystalline; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Molecular Sequence Data; Mutation; Polymorphism, Single Nucleotide; Protein Structure, Tertiary; Receptor, EphA2; Sequence Alignment; Visual Cortex
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161673
• Institution: National University of Singapore

10.1371/journal.pgen.1000584