MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis

• Main Authors: Bowdish D.M.E., Sakamoto K., Kim M.-J., Kroos M., Mukhopadhyay S., Leifer C.A., Tryggvason K., Gordon S., Russell D.G.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: CD14 antigen; cord factor; immunoglobulin enhancer binding protein; interleukin 1beta; interleukin 6; marco receptor; mitogen activated protein kinase; mitogen activated protein kinase 1; mitogen activated protein kinase 3; myeloid differentiation factor 88; protein MD 2; scavenger receptor A; toll like receptor 2; toll like receptor 4; tumor necrosis factor alpha; unclassified drug; cytokine; immunoglobulin receptor; MARCO protein, human; Marco protein, mouse; microsphere; TLR2 protein, human; TLR4 protein, human; animal cell; animal experiment; article; controlled study; cytokine production; enzyme activation; enzyme phosphorylation; human; human cell; mouse; Mycobacterium tuberculosis; nonhuman; peritoneum macrophage; phagosome; protein expression; protein localization; receptor binding; signal transduction; animal; C57BL mouse; CHO cell; Cricetulus; cytoplasm; fluorescence microscopy; genetics; hamster; immunology; macrophage; metabolism; Mus; Animals; Antigens, CD14; CHO Cells; Cord Factors; Cricetinae; Cytokines; Cytoplasm; Humans; Macrophages; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Microspheres; Phagosomes; Receptors, Immunologic; Scavenger Receptors, Class A; Signal Transduction; Toll-Like Receptor 2; Toll-Like Receptor 4
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161674
• Institution: National University of Singapore

10.1371/journal.ppat.1000474