Alphavirus replicon DNA expressing HIV antigens is an excellent prime for boosting with recombinant Modified Vaccinia Ankara (MVA) or with HIV gp140 protein antigen

• Main Authors: Knudsen M.L., Ljungberg K., Tatoud R., Weber J., Esteban M., Liljeström P.
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: 2019
• Subjects: glycoprotein gp 140; Human immunodeficiency virus antigen; Human immunodeficiency virus vaccine; hybrid protein; immunoglobulin G; modified vaccinia virus Ankara vaccine; poxvirus vector; unclassified drug; vaccinia vaccine; virus DNA; DNA vaccine; gp140 envelope protein, Human immunodeficiency virus 1; lipid A; recombinant DNA; virus antibody; virus envelope protein; Alpha virus; animal cell; animal experiment; animal model; antigen expression; Article; controlled study; drug formulation; female; gene sequence; genetic code; Human immunodeficiency virus infection; immune response; immunization; in vivo study; mouse; nonhuman; T lymphocyte; Alphavirus; animal; Bagg albino mouse; chemistry; gene expression; gene vector; genetics; Human immunodeficiency virus 1; immunology; medicinal chemistry; replicon; Vaccinia virus; Poxviridae; Animals; Antibodies, Viral; Chemistry, Pharmaceutical; DNA, Recombinant; DNA, Viral; env Gene Products, Human Immunodeficiency Virus; Female; Gene Expression; Genetic Vectors; HIV Antigens; HIV-1; Immunization, Secondary; Immunoglobulin G; Lipid A; Mice; Mice, Inbred BALB C; Replicon; T-Lymphocytes; Vaccines, DNA
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161750
• Institution: National University of Singapore

10.1371/journal.pone.0117042