Superior induction of T cell responses to conserved HIV-1 regions by electroporated alphavirus replicon DNA compared to that with conventional plasmid DNA vaccine

• Main Authors: Knudsen, M.L, Mbewe-Mvula, A, Rosario, M, Johansson, D.X, Kakoulidou, M, Bridgeman, A, Reyes-Sandoval, A, Nicosia, A.CEINGE, Naples, Italy, Department of Biotechnology, University of Naples, Naples, Italy, Ljungberg, K, Hanke, T, Liljeström, P
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: 2020
• Subjects: adenovirus vector; Human immunodeficiency virus vaccine; plasmid DNA; animal cell; animal experiment; animal tissue; article; CD4+ T lymphocyte; CD8+ T lymphocyte; cladistics; controlled study; DNA vector; dose response; drug dose comparison; drug dose reduction; drug dose titration; drug megadose; drug potency; electroporation; female; Human immunodeficiency virus 1; immunogenicity; immunomodulation; immunoreactivity; in vivo study; intermethod comparison; low drug dose; Macaca mulatta; mouse; nonhuman; priority journal; replicon; Semliki Forest alphavirus; T lymphocyte activation; vaccine production; Vaccinia virus; AIDS Vaccines; Animals; CD8-Positive T-Lymphocytes; Cell Line; DNA, Viral; Electroporation; Female; Gene Order; HIV Infections; HIV-1; Humans; Mice; Mice, Inbred BALB C; Plasmids; Semliki forest virus; T-Lymphocytes; Vaccines, DNA; Alphavirus; Chimpanzee adenovirus; Vaccinia virus Ankara
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/180839
• Institution: National University of Singapore

10.1128/JVI.06535-11