VKORC1 pharmacogenetics and pharmacoproteomics in patients on warfarin anticoagulant therapy: Transthyretin precursor as a potential biomarker

• Main Authors: Saminathan R., Bai J., Sadrolodabaee L., Karthik G.M., Singh O., Subramaniyan K., Ching C.B., Chen W.N., Chowbay B.
• Other Authors: CHEMICAL & BIOMOLECULAR ENGINEERING
• Format: Article
• Published: 2019
• Subjects: biological marker; interleukin 6; multiprotein complex; prealbumin; unclassified drug; vitamin K epoxide reductase complex subunit 1; vitamin K group; warfarin; anticoagulant agent; menadione epoxidase; mixed function oxidase; adult; aged; anticoagulant therapy; article; cell strain HepG2; controlled study; drug dose comparison; drug megadose; enzyme linked immunosorbent assay; female; gene expression profiling; genetic polymorphism; human; human cell; liquid chromatography; low drug dose; major clinical study; male; pharmacogenetics; proteomics; real time polymerase chain reaction; reverse transcription polymerase chain reaction; tandem mass spectrometry; upregulation; Western blotting; biosynthesis; cohort analysis; genetics; liver; metabolism; methodology; tumor cell line; Anticoagulants; Biological Markers; Cell Line, Tumor; Cohort Studies; Enzyme-Linked Immunosorbent Assay; Humans; Interleukin-6; Liver; Mixed Function Oxygenases; Pharmacogenetics; Polymorphism, Genetic; Prealbumin; Proteomics; Reverse Transcriptase Polymerase Chain Reaction; Tandem Mass Spectrometry; Warfarin
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161800
• Institution: National University of Singapore

10.1371/journal.pone.0015064