VKORC1 pharmacogenetics and pharmacoproteomics in patients on warfarin anticoagulant therapy: Transthyretin precursor as a potential biomarker

10.1371/journal.pone.0015064

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Main Authors:	Saminathan R., Bai J., Sadrolodabaee L., Karthik G.M., Singh O., Subramaniyan K., Ching C.B., Chen W.N., Chowbay B.
Other Authors:	CHEMICAL & BIOMOLECULAR ENGINEERING
Format:	Article
Published:	2019
Subjects:	biological marker interleukin 6 multiprotein complex prealbumin unclassified drug vitamin K epoxide reductase complex subunit 1 vitamin K group warfarin anticoagulant agent menadione epoxidase mixed function oxidase adult aged anticoagulant therapy article cell strain HepG2 controlled study drug dose comparison drug megadose enzyme linked immunosorbent assay female gene expression profiling genetic polymorphism human human cell liquid chromatography low drug dose major clinical study male pharmacogenetics proteomics real time polymerase chain reaction reverse transcription polymerase chain reaction tandem mass spectrometry upregulation Western blotting biosynthesis cohort analysis genetics liver metabolism methodology tumor cell line Anticoagulants Biological Markers Cell Line, Tumor Cohort Studies Enzyme-Linked Immunosorbent Assay Humans Interleukin-6 Liver Mixed Function Oxygenases Pharmacogenetics Polymorphism, Genetic Prealbumin Proteomics Reverse Transcriptase Polymerase Chain Reaction Tandem Mass Spectrometry Warfarin
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161800
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1618002024-03-26T08:57:18Z VKORC1 pharmacogenetics and pharmacoproteomics in patients on warfarin anticoagulant therapy: Transthyretin precursor as a potential biomarker Saminathan R. Bai J. Sadrolodabaee L. Karthik G.M. Singh O. Subramaniyan K. Ching C.B. Chen W.N. Chowbay B. CHEMICAL & BIOMOLECULAR ENGINEERING TEMASEK LABORATORIES DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL) DUKE-NUS MEDICAL SCHOOL biological marker interleukin 6 multiprotein complex prealbumin unclassified drug vitamin K epoxide reductase complex subunit 1 vitamin K group warfarin anticoagulant agent biological marker interleukin 6 menadione epoxidase mixed function oxidase prealbumin warfarin adult aged anticoagulant therapy article cell strain HepG2 controlled study drug dose comparison drug megadose enzyme linked immunosorbent assay female gene expression profiling genetic polymorphism human human cell liquid chromatography low drug dose major clinical study male pharmacogenetics proteomics real time polymerase chain reaction reverse transcription polymerase chain reaction tandem mass spectrometry upregulation Western blotting biosynthesis cohort analysis genetics liver metabolism methodology tumor cell line Anticoagulants Biological Markers Cell Line, Tumor Cohort Studies Enzyme-Linked Immunosorbent Assay Humans Interleukin-6 Liver Mixed Function Oxygenases Pharmacogenetics Polymorphism, Genetic Prealbumin Proteomics Reverse Transcriptase Polymerase Chain Reaction Tandem Mass Spectrometry Warfarin 10.1371/journal.pone.0015064 PLoS ONE 5 12 e15064 2019-11-07T07:59:35Z 2019-11-07T07:59:35Z 2010 Article Saminathan R., Bai J., Sadrolodabaee L., Karthik G.M., Singh O., Subramaniyan K., Ching C.B., Chen W.N., Chowbay B. (2010). VKORC1 pharmacogenetics and pharmacoproteomics in patients on warfarin anticoagulant therapy: Transthyretin precursor as a potential biomarker. PLoS ONE 5 (12) : e15064. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0015064 19326203 https://scholarbank.nus.edu.sg/handle/10635/161800 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	biological marker interleukin 6 multiprotein complex prealbumin unclassified drug vitamin K epoxide reductase complex subunit 1 vitamin K group warfarin anticoagulant agent biological marker interleukin 6 menadione epoxidase mixed function oxidase prealbumin warfarin adult aged anticoagulant therapy article cell strain HepG2 controlled study drug dose comparison drug megadose enzyme linked immunosorbent assay female gene expression profiling genetic polymorphism human human cell liquid chromatography low drug dose major clinical study male pharmacogenetics proteomics real time polymerase chain reaction reverse transcription polymerase chain reaction tandem mass spectrometry upregulation Western blotting biosynthesis cohort analysis genetics liver metabolism methodology tumor cell line Anticoagulants Biological Markers Cell Line, Tumor Cohort Studies Enzyme-Linked Immunosorbent Assay Humans Interleukin-6 Liver Mixed Function Oxygenases Pharmacogenetics Polymorphism, Genetic Prealbumin Proteomics Reverse Transcriptase Polymerase Chain Reaction Tandem Mass Spectrometry Warfarin
spellingShingle	biological marker interleukin 6 multiprotein complex prealbumin unclassified drug vitamin K epoxide reductase complex subunit 1 vitamin K group warfarin anticoagulant agent biological marker interleukin 6 menadione epoxidase mixed function oxidase prealbumin warfarin adult aged anticoagulant therapy article cell strain HepG2 controlled study drug dose comparison drug megadose enzyme linked immunosorbent assay female gene expression profiling genetic polymorphism human human cell liquid chromatography low drug dose major clinical study male pharmacogenetics proteomics real time polymerase chain reaction reverse transcription polymerase chain reaction tandem mass spectrometry upregulation Western blotting biosynthesis cohort analysis genetics liver metabolism methodology tumor cell line Anticoagulants Biological Markers Cell Line, Tumor Cohort Studies Enzyme-Linked Immunosorbent Assay Humans Interleukin-6 Liver Mixed Function Oxygenases Pharmacogenetics Polymorphism, Genetic Prealbumin Proteomics Reverse Transcriptase Polymerase Chain Reaction Tandem Mass Spectrometry Warfarin Saminathan R. Bai J. Sadrolodabaee L. Karthik G.M. Singh O. Subramaniyan K. Ching C.B. Chen W.N. Chowbay B. VKORC1 pharmacogenetics and pharmacoproteomics in patients on warfarin anticoagulant therapy: Transthyretin precursor as a potential biomarker
description	10.1371/journal.pone.0015064
author2	CHEMICAL & BIOMOLECULAR ENGINEERING
author_facet	CHEMICAL & BIOMOLECULAR ENGINEERING Saminathan R. Bai J. Sadrolodabaee L. Karthik G.M. Singh O. Subramaniyan K. Ching C.B. Chen W.N. Chowbay B.
format	Article
author	Saminathan R. Bai J. Sadrolodabaee L. Karthik G.M. Singh O. Subramaniyan K. Ching C.B. Chen W.N. Chowbay B.
author_sort	Saminathan R.
title	VKORC1 pharmacogenetics and pharmacoproteomics in patients on warfarin anticoagulant therapy: Transthyretin precursor as a potential biomarker
title_short	VKORC1 pharmacogenetics and pharmacoproteomics in patients on warfarin anticoagulant therapy: Transthyretin precursor as a potential biomarker
title_full	VKORC1 pharmacogenetics and pharmacoproteomics in patients on warfarin anticoagulant therapy: Transthyretin precursor as a potential biomarker
title_fullStr	VKORC1 pharmacogenetics and pharmacoproteomics in patients on warfarin anticoagulant therapy: Transthyretin precursor as a potential biomarker
title_full_unstemmed	VKORC1 pharmacogenetics and pharmacoproteomics in patients on warfarin anticoagulant therapy: Transthyretin precursor as a potential biomarker
title_sort	vkorc1 pharmacogenetics and pharmacoproteomics in patients on warfarin anticoagulant therapy: transthyretin precursor as a potential biomarker
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161800
_version_	1795300780152979456

VKORC1 pharmacogenetics and pharmacoproteomics in patients on warfarin anticoagulant therapy: Transthyretin precursor as a potential biomarker

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