Graded Smad2/3 activation is converted directly into levels of target gene expression in embryonic stem cells

• Main Authors: Guzman-Ayala M., Lee K.L., Mavrakis K.J., Goggolidou P., Norris D.P., Episkopou V.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: 4 [4 (1,3 benzodioxol 5 yl) 5 (2 pyridinyl) 1h imidazol 2 yl]benzamide; Smad2 protein; Smad3 protein; Smad7 protein; 1,3 dioxolane derivative; 4 (5 benzo(1,3)dioxol 5 yl 4 pyridin 2 yl 1H imidazol 2 yl)benzamide; 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide; activin receptor 1; Acvr1b protein, mouse; Arkadia protein, mouse; benzamide derivative; Nodal protein, mouse; protein Nodal; Smad2 protein, mouse; Smad3 protein, mouse; transforming growth factor beta; ubiquitin; animal cell; animal tissue; article; controlled study; DNA microarray; embryo; embryo development; embryonic stem cell; feedback system; gene activation; gene expression profiling; gene identification; gene repression; genetic transcription; morphogenesis; mouse; nonhuman; nucleotide sequence; protein synthesis; signal transduction; transcription regulation; unindexed sequence; animal; biological model; flow cytometry; gene expression regulation; metabolism; Vertebrata; Activin Receptors, Type I; Animals; Benzamides; Dioxoles; Embryonic Stem Cells; Flow Cytometry; Gene Expression Regulation, Developmental; Mice; Models, Biological; Nodal Protein; Signal Transduction; Smad2 Protein; Smad3 Protein; Transcription, Genetic; Transforming Growth Factor beta; Ubiquitin
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161843
• Institution: National University of Singapore

10.1371/journal.pone.0004268