Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition

• Main Authors: Ong C.-T., Sedy J.R., Murphy K.M., Kopan R.
• Other Authors: BIOLOGY
• Format: Article
• Published: 2019
• Subjects: CD4 antigen; cytokine; gamma secretase; immunoglobulin J recombination signal sequence binding protein; interleukin 12; interleukin 4; Jagged1; Notch receptor; Notch1 receptor; Notch2 receptor; presenilin; animal cell; article; CD4+ T lymphocyte; cell expansion; cell fate; controlled study; cytokine production; cytokine release; human; human cell; lymphocyte differentiation; lymphocyte proliferation; mouse; nonhuman; protein degradation; protein expression; protein function; Th1 cell; Th2 cell; animal; C57BL mouse; cell differentiation; cell lineage; CHO cell; Cricetulus; hamster; metabolism; Animals; Cell Differentiation; Cell Lineage; CHO Cells; Cricetinae; Cytokines; Interleukin-12; Interleukin-4; Mice; Mice, Inbred C57BL; Presenilins; Receptors, Notch; Th1 Cells; Th2 Cells
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161850
• Institution: National University of Singapore

10.1371/journal.pone.0002823