Saturated fatty acids modulate cell response to DNA damage: Implication for their role in tumorigenesis

10.1371/journal.pone.0002329

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Main Authors: Zeng L., Wu G.-Z., Goh K.J., Lee Y.M., Ng C.C., You A.B., Wang J., Jia D., Hao A., Yu Q., Li B.
Other Authors: PHYSIOLOGY
Format: Article
Published: 2019
Subjects:
DNA
Online Access:https://scholarbank.nus.edu.sg/handle/10635/161854
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Institution: National University of Singapore
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spelling sg-nus-scholar.10635-1618542024-11-10T21:25:24Z Saturated fatty acids modulate cell response to DNA damage: Implication for their role in tumorigenesis Zeng L. Wu G.-Z. Goh K.J. Lee Y.M. Ng C.C. You A.B. Wang J. Jia D. Hao A. Yu Q. Li B. PHYSIOLOGY BIOLOGICAL SCIENCES DUKE-NUS MEDICAL SCHOOL actin DNA double stranded DNA doxorubicin fatty acid synthase hydroxyurea myristic acid palmitic acid protein Bax protein p21 protein p53 saturated fatty acid single stranded DNA stearic acid fatty acid fatty acid synthase protein p21 protein p53 animal cell apoptosis article cancer cell carcinogenesis cell cycle arrest cell proliferation cell strain 3T3 cell strain HCT116 cell strain MCF 7 cell transformation controlled study DNA damage DNA strand breakage embryo enzyme inhibition fatty acid synthesis fibroblast gene expression regulation growth inhibition human human cell malignant neoplastic disease mouse nonhuman osteoblast protein expression signal transduction tumor growth animal biosynthesis cell line drug antagonism drug effect fluorescent antibody technique ionizing radiation metabolism phosphorylation physiology Western blotting Murinae Animals Blotting, Western Cell Line Cell Proliferation DNA Damage Doxorubicin Fatty Acid Synthetase Complex Fatty Acids Fluorescent Antibody Technique Humans Hydroxyurea Mice Oncogene Protein p21(ras) Osteoblasts Phosphorylation Radiation, Ionizing Tumor Suppressor Protein p53 10.1371/journal.pone.0002329 PLoS ONE 3 6 e2329 2019-11-08T00:56:28Z 2019-11-08T00:56:28Z 2008 Article Zeng L., Wu G.-Z., Goh K.J., Lee Y.M., Ng C.C., You A.B., Wang J., Jia D., Hao A., Yu Q., Li B. (2008). Saturated fatty acids modulate cell response to DNA damage: Implication for their role in tumorigenesis. PLoS ONE 3 (6) : e2329. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0002329 19326203 https://scholarbank.nus.edu.sg/handle/10635/161854 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution National University of Singapore
building NUS Library
continent Asia
country Singapore
Singapore
content_provider NUS Library
collection ScholarBank@NUS
topic actin
DNA
double stranded DNA
doxorubicin
fatty acid synthase
hydroxyurea
myristic acid
palmitic acid
protein Bax
protein p21
protein p53
saturated fatty acid
single stranded DNA
stearic acid
fatty acid
fatty acid synthase
protein p21
protein p53
animal cell
apoptosis
article
cancer cell
carcinogenesis
cell cycle arrest
cell proliferation
cell strain 3T3
cell strain HCT116
cell strain MCF 7
cell transformation
controlled study
DNA damage
DNA strand breakage
embryo
enzyme inhibition
fatty acid synthesis
fibroblast
gene expression regulation
growth inhibition
human
human cell
malignant neoplastic disease
mouse
nonhuman
osteoblast
protein expression
signal transduction
tumor growth
animal
biosynthesis
cell line
drug antagonism
drug effect
fluorescent antibody technique
ionizing radiation
metabolism
phosphorylation
physiology
Western blotting
Murinae
Animals
Blotting, Western
Cell Line
Cell Proliferation
DNA Damage
Doxorubicin
Fatty Acid Synthetase Complex
Fatty Acids
Fluorescent Antibody Technique
Humans
Hydroxyurea
Mice
Oncogene Protein p21(ras)
Osteoblasts
Phosphorylation
Radiation, Ionizing
Tumor Suppressor Protein p53
spellingShingle actin
DNA
double stranded DNA
doxorubicin
fatty acid synthase
hydroxyurea
myristic acid
palmitic acid
protein Bax
protein p21
protein p53
saturated fatty acid
single stranded DNA
stearic acid
fatty acid
fatty acid synthase
protein p21
protein p53
animal cell
apoptosis
article
cancer cell
carcinogenesis
cell cycle arrest
cell proliferation
cell strain 3T3
cell strain HCT116
cell strain MCF 7
cell transformation
controlled study
DNA damage
DNA strand breakage
embryo
enzyme inhibition
fatty acid synthesis
fibroblast
gene expression regulation
growth inhibition
human
human cell
malignant neoplastic disease
mouse
nonhuman
osteoblast
protein expression
signal transduction
tumor growth
animal
biosynthesis
cell line
drug antagonism
drug effect
fluorescent antibody technique
ionizing radiation
metabolism
phosphorylation
physiology
Western blotting
Murinae
Animals
Blotting, Western
Cell Line
Cell Proliferation
DNA Damage
Doxorubicin
Fatty Acid Synthetase Complex
Fatty Acids
Fluorescent Antibody Technique
Humans
Hydroxyurea
Mice
Oncogene Protein p21(ras)
Osteoblasts
Phosphorylation
Radiation, Ionizing
Tumor Suppressor Protein p53
Zeng L.
Wu G.-Z.
Goh K.J.
Lee Y.M.
Ng C.C.
You A.B.
Wang J.
Jia D.
Hao A.
Yu Q.
Li B.
Saturated fatty acids modulate cell response to DNA damage: Implication for their role in tumorigenesis
description 10.1371/journal.pone.0002329
author2 PHYSIOLOGY
author_facet PHYSIOLOGY
Zeng L.
Wu G.-Z.
Goh K.J.
Lee Y.M.
Ng C.C.
You A.B.
Wang J.
Jia D.
Hao A.
Yu Q.
Li B.
format Article
author Zeng L.
Wu G.-Z.
Goh K.J.
Lee Y.M.
Ng C.C.
You A.B.
Wang J.
Jia D.
Hao A.
Yu Q.
Li B.
author_sort Zeng L.
title Saturated fatty acids modulate cell response to DNA damage: Implication for their role in tumorigenesis
title_short Saturated fatty acids modulate cell response to DNA damage: Implication for their role in tumorigenesis
title_full Saturated fatty acids modulate cell response to DNA damage: Implication for their role in tumorigenesis
title_fullStr Saturated fatty acids modulate cell response to DNA damage: Implication for their role in tumorigenesis
title_full_unstemmed Saturated fatty acids modulate cell response to DNA damage: Implication for their role in tumorigenesis
title_sort saturated fatty acids modulate cell response to dna damage: implication for their role in tumorigenesis
publishDate 2019
url https://scholarbank.nus.edu.sg/handle/10635/161854
_version_ 1821194051707207680