Saturated fatty acids modulate cell response to DNA damage: Implication for their role in tumorigenesis

• Main Authors: Zeng L., Wu G.-Z., Goh K.J., Lee Y.M., Ng C.C., You A.B., Wang J., Jia D., Hao A., Yu Q., Li B.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: actin; DNA; double stranded DNA; doxorubicin; fatty acid synthase; hydroxyurea; myristic acid; palmitic acid; protein Bax; protein p21; protein p53; saturated fatty acid; single stranded DNA; stearic acid; fatty acid; animal cell; apoptosis; article; cancer cell; carcinogenesis; cell cycle arrest; cell proliferation; cell strain 3T3; cell strain HCT116; cell strain MCF 7; cell transformation; controlled study; DNA damage; DNA strand breakage; embryo; enzyme inhibition; fatty acid synthesis; fibroblast; gene expression regulation; growth inhibition; human; human cell; malignant neoplastic disease; mouse; nonhuman; osteoblast; protein expression; signal transduction; tumor growth; animal; biosynthesis; cell line; drug antagonism; drug effect; fluorescent antibody technique; ionizing radiation; metabolism; phosphorylation; physiology; Western blotting; Murinae; Animals; Blotting, Western; Cell Line; Cell Proliferation; DNA Damage; Doxorubicin; Fatty Acid Synthetase Complex; Fatty Acids; Fluorescent Antibody Technique; Humans; Hydroxyurea; Mice; Oncogene Protein p21(ras); Osteoblasts; Phosphorylation; Radiation, Ionizing; Tumor Suppressor Protein p53
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161854
• Institution: National University of Singapore

10.1371/journal.pone.0002329