Nonvirally modified autologous primary hepatocytes correct diabetes and prevent target organ injury in a large preclinical model

10.1371/journal.pone.0001734

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Main Authors:	Chen N.K.F., Wong J.S., Kee I.H.C., Lai S.H., Thng C.H., Ng W.H., Ng R.T.H., Tan S.Y., Lee S.Y., Tan M.E.H., Sivalingam J., Chow P.K.H., Kon O.L.
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	2019
Subjects:	C peptide complementary DNA glucose insulin messenger RNA transcriptome streptozocin animal cell animal experiment animal model animal tissue aorta article cell isolation cell transplantation controlled study diabetes mellitus dyslipidemia electroporation ex vivo study expression vector eye female gene transfer glucose blood level glucose intolerance hyperglycemia kidney liver liver cell liver function male metabolic disorder nonhuman organ injury plasmid streptozocin diabetes swine animal DNA microarray experimental diabetes mellitus gene expression profiling gene therapy genetics glucose tolerance test human injury metabolism pancreas islet beta cell pathology radioimmunoassay retina reverse transcription polymerase chain reaction secretion transplantation Suidae Animals Aorta Blood Glucose C-Peptide Diabetes Mellitus, Experimental Electroporation Gene Expression Profiling Gene Therapy Gene Transfer Techniques Glucose Tolerance Test Hepatocytes Humans Insulin Insulin-Secreting Cells Kidney Liver Oligonucleotide Array Sequence Analysis Radioimmunoassay Retina Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger Streptozocin Swine
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161858
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1618582024-04-03T07:38:42Z Nonvirally modified autologous primary hepatocytes correct diabetes and prevent target organ injury in a large preclinical model Chen N.K.F. Wong J.S. Kee I.H.C. Lai S.H. Thng C.H. Ng W.H. Ng R.T.H. Tan S.Y. Lee S.Y. Tan M.E.H. Sivalingam J. Chow P.K.H. Kon O.L. DUKE-NUS MEDICAL SCHOOL PATHOLOGY C peptide complementary DNA glucose insulin messenger RNA transcriptome C peptide insulin messenger RNA streptozocin animal cell animal experiment animal model animal tissue aorta article cell isolation cell transplantation controlled study diabetes mellitus dyslipidemia electroporation ex vivo study expression vector eye female gene transfer glucose blood level glucose intolerance hyperglycemia kidney liver liver cell liver function male metabolic disorder nonhuman organ injury plasmid streptozocin diabetes swine animal DNA microarray experimental diabetes mellitus gene expression profiling gene therapy genetics glucose tolerance test human injury metabolism pancreas islet beta cell pathology radioimmunoassay retina reverse transcription polymerase chain reaction secretion transplantation Suidae Animals Aorta Blood Glucose C-Peptide Diabetes Mellitus, Experimental Electroporation Gene Expression Profiling Gene Therapy Gene Transfer Techniques Glucose Tolerance Test Hepatocytes Humans Insulin Insulin-Secreting Cells Kidney Liver Oligonucleotide Array Sequence Analysis Radioimmunoassay Retina Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger Streptozocin Swine 10.1371/journal.pone.0001734 PLoS ONE 3 3 e1734 2019-11-08T00:57:13Z 2019-11-08T00:57:13Z 2008 Article Chen N.K.F., Wong J.S., Kee I.H.C., Lai S.H., Thng C.H., Ng W.H., Ng R.T.H., Tan S.Y., Lee S.Y., Tan M.E.H., Sivalingam J., Chow P.K.H., Kon O.L. (2008). Nonvirally modified autologous primary hepatocytes correct diabetes and prevent target organ injury in a large preclinical model. PLoS ONE 3 (3) : e1734. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0001734 19326203 https://scholarbank.nus.edu.sg/handle/10635/161858 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	C peptide complementary DNA glucose insulin messenger RNA transcriptome C peptide insulin messenger RNA streptozocin animal cell animal experiment animal model animal tissue aorta article cell isolation cell transplantation controlled study diabetes mellitus dyslipidemia electroporation ex vivo study expression vector eye female gene transfer glucose blood level glucose intolerance hyperglycemia kidney liver liver cell liver function male metabolic disorder nonhuman organ injury plasmid streptozocin diabetes swine animal DNA microarray experimental diabetes mellitus gene expression profiling gene therapy genetics glucose tolerance test human injury metabolism pancreas islet beta cell pathology radioimmunoassay retina reverse transcription polymerase chain reaction secretion transplantation Suidae Animals Aorta Blood Glucose C-Peptide Diabetes Mellitus, Experimental Electroporation Gene Expression Profiling Gene Therapy Gene Transfer Techniques Glucose Tolerance Test Hepatocytes Humans Insulin Insulin-Secreting Cells Kidney Liver Oligonucleotide Array Sequence Analysis Radioimmunoassay Retina Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger Streptozocin Swine
spellingShingle	C peptide complementary DNA glucose insulin messenger RNA transcriptome C peptide insulin messenger RNA streptozocin animal cell animal experiment animal model animal tissue aorta article cell isolation cell transplantation controlled study diabetes mellitus dyslipidemia electroporation ex vivo study expression vector eye female gene transfer glucose blood level glucose intolerance hyperglycemia kidney liver liver cell liver function male metabolic disorder nonhuman organ injury plasmid streptozocin diabetes swine animal DNA microarray experimental diabetes mellitus gene expression profiling gene therapy genetics glucose tolerance test human injury metabolism pancreas islet beta cell pathology radioimmunoassay retina reverse transcription polymerase chain reaction secretion transplantation Suidae Animals Aorta Blood Glucose C-Peptide Diabetes Mellitus, Experimental Electroporation Gene Expression Profiling Gene Therapy Gene Transfer Techniques Glucose Tolerance Test Hepatocytes Humans Insulin Insulin-Secreting Cells Kidney Liver Oligonucleotide Array Sequence Analysis Radioimmunoassay Retina Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger Streptozocin Swine Chen N.K.F. Wong J.S. Kee I.H.C. Lai S.H. Thng C.H. Ng W.H. Ng R.T.H. Tan S.Y. Lee S.Y. Tan M.E.H. Sivalingam J. Chow P.K.H. Kon O.L. Nonvirally modified autologous primary hepatocytes correct diabetes and prevent target organ injury in a large preclinical model
description	10.1371/journal.pone.0001734
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Chen N.K.F. Wong J.S. Kee I.H.C. Lai S.H. Thng C.H. Ng W.H. Ng R.T.H. Tan S.Y. Lee S.Y. Tan M.E.H. Sivalingam J. Chow P.K.H. Kon O.L.
format	Article
author	Chen N.K.F. Wong J.S. Kee I.H.C. Lai S.H. Thng C.H. Ng W.H. Ng R.T.H. Tan S.Y. Lee S.Y. Tan M.E.H. Sivalingam J. Chow P.K.H. Kon O.L.
author_sort	Chen N.K.F.
title	Nonvirally modified autologous primary hepatocytes correct diabetes and prevent target organ injury in a large preclinical model
title_short	Nonvirally modified autologous primary hepatocytes correct diabetes and prevent target organ injury in a large preclinical model
title_full	Nonvirally modified autologous primary hepatocytes correct diabetes and prevent target organ injury in a large preclinical model
title_fullStr	Nonvirally modified autologous primary hepatocytes correct diabetes and prevent target organ injury in a large preclinical model
title_full_unstemmed	Nonvirally modified autologous primary hepatocytes correct diabetes and prevent target organ injury in a large preclinical model
title_sort	nonvirally modified autologous primary hepatocytes correct diabetes and prevent target organ injury in a large preclinical model
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161858
_version_	1795374117446221824

Nonvirally modified autologous primary hepatocytes correct diabetes and prevent target organ injury in a large preclinical model

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