Microvesicles from malaria-infected red blood cells activate natural killer cells via MDA5 pathway

• Main Authors: Ye W., Chew M., Hou J., Lai F., Leopold S.J., Loo H.L., Ghose A., Dutta A.K., Chen Q., Ooi E.E., White N.J., Dondorp A.M., Preiser P., Chen J.
• Other Authors: MEDICINE
• Format: Article
• Published: 2019
• Subjects: bilirubin; CD69 antigen; creatinine; gamma interferon; granulysin; interferon induced helicase C domain containing protein 1; interleukin 2 receptor alpha; lectin receptor; lysosome associated membrane protein 1; natural killer cell receptor NKG2A; natural killer cell receptor NKG2D; IFIH1 protein, human; adult; Article; cell heterogeneity; confocal microscopy; controlled study; cytotoxicity; discriminant analysis; erythrocyte; female; flow cytometry; gel electrophoresis; gene expression; hematocrit; human; human cell; hypoglycemia; immune response; immunoassay; malaria; male; membrane microparticle; microarray analysis; natural killer T cell; parasitemia; peripheral blood mononuclear cell; Plasmodium falciparum; protein expression; respiratory failure; reverse transcription; RNA isolation; signal transduction; systolic blood pressure; Western blotting; antagonists and inhibitors; cell culture; CRISPR Cas system; cytoplasm; genetics; immunology; isolation and purification; lymphocyte activation; malaria falciparum; metabolism; natural killer cell; parasitology; Cell-Derived Microparticles; Cells, Cultured; CRISPR-Cas Systems; Cytoplasm; Erythrocytes; Humans; Interferon-Induced Helicase, IFIH1; Killer Cells, Natural; Lymphocyte Activation; Malaria, Falciparum
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161879
• Institution: National University of Singapore

10.1371/journal.ppat.1007298