Reduced monocyte and macrophage TNFSF15/TL1A expression is associated with susceptibility to inflammatory bowel disease

• Main Authors: Richard A.C., Peters J.E., Savinykh N., Lee J.C., Hawley E.T., Meylan F., Siegel R.M., Lyons P.A., Smith K.G.C.
• Other Authors: MEDICINE
• Format: Article
• Published: 2019
• Subjects: RNA; vascular endothelial growth inhibitor; TNFSF15 protein, human; adult; aged; allele; Article; Caucasian; cell differentiation; controlled study; disease association; disease predisposition; female; gene expression; gene mapping; genetic risk; haplotype; human; human cell; inflammatory bowel disease; macrophage; major clinical study; male; middle aged; monocyte; protein function; T lymphocyte; TNFSF15 gene; young adult; blood; cell culture; Crohn disease; genetic predisposition; genetics; immunology; metabolism; primary cell culture; quantitative trait locus; single nucleotide polymorphism; ulcerative colitis; Adult; Alleles; Cells, Cultured; Colitis, Ulcerative; Crohn Disease; Female; Genetic Predisposition to Disease; Haplotypes; Humans; Macrophages; Male; Middle Aged; Monocytes; Polymorphism, Single Nucleotide; Primary Cell Culture; Quantitative Trait Loci; Tumor Necrosis Factor Ligand Superfamily Member 15; Young Adult
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161880
• Institution: National University of Singapore

10.1371/journal.pgen.1007458