The Janus-faced Nature of miR-22 in Hematopoiesis: Is It an Oncogenic Tumor Suppressor or Rather a Tumor-Suppressive Oncogene?

• Main Authors: Wurm A.A., Tenen D.G., Behre G.
• Other Authors: MEDICINE
• Format: Article
• Published: 2019
• Subjects: CCAAT enhancer binding protein alpha; Janus kinase; microRNA; microRNA 181; microRNA 22; mixed lineage leukemia protein; transcription factor PU 1; unclassified drug; MIRN22 microRNA, human; acute myeloid leukemia; Article; cell differentiation; cell lineage; gene expression; hematopoiesis; human; leukemogenesis; malignant transformation; monocyte; myelodysplastic syndrome; myelopoiesis; nonhuman; oncogene; macrophage; tumor suppressor gene; Genes, Tumor Suppressor; Hematopoiesis; Humans; Leukemia, Myeloid, Acute; Macrophages; MicroRNAs; Monocytes
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161901
• Institution: National University of Singapore

10.1371/journal.pgen.1006505