Discovery of Influenza A Virus Sequence Pairs and Their Combinations for Simultaneous Heterosubtypic Targeting that Hedge against Antiviral Resistance

• Main Authors: Wee K.B., Lee R.T.C., Lin J., Pramono Z.A.D., Maurer-Stroh S.
• Other Authors: BIOLOGICAL SCIENCES
• Format: Article
• Published: 2019
• Subjects: antivirus agent; antiviral resistance; Article; chicken; controlled study; cross reaction; gene expression; gene mutation; human; Influenza A virus; Influenza B virus; Monte Carlo method; nonhuman; pig; RNA binding; RNA sequence; sequence alignment; thermostability; virus cell interaction; virus titration; animal; biology; computer simulation; conserved sequence; drug effects; gene expression profiling; genetics; host pathogen interaction; influenza; nucleotide sequence; orthomyxovirus infection; virology; Animals; Antiviral Agents; Base Sequence; Chickens; Computational Biology; Computer Simulation; Conserved Sequence; Drug Resistance, Viral; Gene Expression Profiling; Host-Pathogen Interactions; Humans; Influenza, Human; Orthomyxoviridae Infections; Swine
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161925
• Institution: National University of Singapore

10.1371/journal.pcbi.1004663