Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis

• Main Authors: Ong C.W.M., Elkington P.T., Brilha S., Ugarte-Gil C., Tome-Esteban M.T., Tezera L.B., Pabisiak P.J., Moores R.C., Sathyamoorthy T., Patel V., Gilman R.H., Porter J.C., Friedland J.S.
• Other Authors: MEDICINE
• Format: Article
• Published: 2019
• Subjects: collagen type 1; gelatin; gelatinase B; hydroxymethylglutaryl coenzyme A reductase kinase; myeloperoxidase; neutrophil collagenase; neutrophil gelatinase associated lipocalin; phosphotransferase; tissue inhibitor of metalloproteinase 1; tissue inhibitor of metalloproteinase 2; enzyme inhibitor; immunoglobulin enhancer binding protein; MMP8 protein, human; scleroprotein; adult; anatomical concepts; Article; cell culture; cell stimulation; controlled study; disease severity; enzyme linked immunosorbent assay; extracellular trap; flow cytometry; human; human tissue; immunoblotting; immunofluorescence microscopy; immunohistochemistry; immunopathology; lung biopsy; lung tuberculosis; major clinical study; matrix destruction; neutrophil; protein degradation; protein expression; real time polymerase chain reaction; upregulation; active transport; chemistry; cohort analysis; drug effects; enzymology; host pathogen interaction; immunology; innate immunity; lung; metabolism; Mycobacterium tuberculosis; neutrophil chemotaxis; pathology; phosphorylation; physiology; protein processing; respiratory mucosa; secretion (process); sputum; Tuberculosis, Pulmonary; Active Transport, Cell Nucleus; Adult; AMP-Activated Protein Kinases; Cells, Cultured; Cohort Studies; Enzyme Inhibitors; Extracellular Matrix Proteins; Host-Pathogen Interactions; Humans; Immunity, Innate; Lung; Matrix Metalloproteinase 8; Neutrophil Infiltration; Neutrophils; NF-kappa B; Phosphorylation; Protein Processing, Post-Translational; Proteolysis; Respiratory Mucosa; Sputum
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161936
• Institution: National University of Singapore

10.1371/journal.ppat.1004917