Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis

10.1371/journal.ppat.1004917

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Main Authors:	Ong C.W.M., Elkington P.T., Brilha S., Ugarte-Gil C., Tome-Esteban M.T., Tezera L.B., Pabisiak P.J., Moores R.C., Sathyamoorthy T., Patel V., Gilman R.H., Porter J.C., Friedland J.S.
Other Authors:	MEDICINE
Format:	Article
Published:	2019
Subjects:	collagen type 1 gelatin gelatinase B hydroxymethylglutaryl coenzyme A reductase kinase myeloperoxidase neutrophil collagenase neutrophil gelatinase associated lipocalin phosphotransferase tissue inhibitor of metalloproteinase 1 tissue inhibitor of metalloproteinase 2 enzyme inhibitor immunoglobulin enhancer binding protein MMP8 protein, human scleroprotein adult anatomical concepts Article cell culture cell stimulation controlled study disease severity enzyme linked immunosorbent assay extracellular trap flow cytometry human human tissue immunoblotting immunofluorescence microscopy immunohistochemistry immunopathology lung biopsy lung tuberculosis major clinical study matrix destruction neutrophil protein degradation protein expression real time polymerase chain reaction upregulation active transport chemistry cohort analysis drug effects enzymology host pathogen interaction immunology innate immunity lung metabolism Mycobacterium tuberculosis neutrophil chemotaxis pathology phosphorylation physiology protein processing respiratory mucosa secretion (process) sputum Tuberculosis, Pulmonary Active Transport, Cell Nucleus Adult AMP-Activated Protein Kinases Cells, Cultured Cohort Studies Enzyme Inhibitors Extracellular Matrix Proteins Host-Pathogen Interactions Humans Immunity, Innate Lung Matrix Metalloproteinase 8 Neutrophil Infiltration Neutrophils NF-kappa B Phosphorylation Protein Processing, Post-Translational Proteolysis Respiratory Mucosa Sputum
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161936
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1619362024-11-08T21:39:11Z Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis Ong C.W.M. Elkington P.T. Brilha S. Ugarte-Gil C. Tome-Esteban M.T. Tezera L.B. Pabisiak P.J. Moores R.C. Sathyamoorthy T. Patel V. Gilman R.H. Porter J.C. Friedland J.S. MEDICINE collagen type 1 gelatin gelatinase B hydroxymethylglutaryl coenzyme A reductase kinase myeloperoxidase neutrophil collagenase neutrophil gelatinase associated lipocalin phosphotransferase tissue inhibitor of metalloproteinase 1 tissue inhibitor of metalloproteinase 2 enzyme inhibitor hydroxymethylglutaryl coenzyme A reductase kinase immunoglobulin enhancer binding protein MMP8 protein, human neutrophil collagenase scleroprotein adult anatomical concepts Article cell culture cell stimulation controlled study disease severity enzyme linked immunosorbent assay extracellular trap flow cytometry human human tissue immunoblotting immunofluorescence microscopy immunohistochemistry immunopathology lung biopsy lung tuberculosis major clinical study matrix destruction neutrophil protein degradation protein expression real time polymerase chain reaction upregulation active transport chemistry cohort analysis drug effects enzymology host pathogen interaction immunology innate immunity lung metabolism Mycobacterium tuberculosis neutrophil neutrophil chemotaxis pathology phosphorylation physiology protein processing respiratory mucosa secretion (process) sputum Tuberculosis, Pulmonary Mycobacterium tuberculosis Active Transport, Cell Nucleus Adult AMP-Activated Protein Kinases Cells, Cultured Cohort Studies Enzyme Inhibitors Extracellular Matrix Proteins Host-Pathogen Interactions Humans Immunity, Innate Lung Matrix Metalloproteinase 8 Mycobacterium tuberculosis Neutrophil Infiltration Neutrophils NF-kappa B Phosphorylation Protein Processing, Post-Translational Proteolysis Respiratory Mucosa Sputum Tuberculosis, Pulmonary 10.1371/journal.ppat.1004917 PLoS Pathogens 11 5 e1004917 2019-11-08T08:47:42Z 2019-11-08T08:47:42Z 2015 Article Ong C.W.M., Elkington P.T., Brilha S., Ugarte-Gil C., Tome-Esteban M.T., Tezera L.B., Pabisiak P.J., Moores R.C., Sathyamoorthy T., Patel V., Gilman R.H., Porter J.C., Friedland J.S. (2015). Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis. PLoS Pathogens 11 (5) : e1004917. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.ppat.1004917 15537366 https://scholarbank.nus.edu.sg/handle/10635/161936 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	collagen type 1 gelatin gelatinase B hydroxymethylglutaryl coenzyme A reductase kinase myeloperoxidase neutrophil collagenase neutrophil gelatinase associated lipocalin phosphotransferase tissue inhibitor of metalloproteinase 1 tissue inhibitor of metalloproteinase 2 enzyme inhibitor hydroxymethylglutaryl coenzyme A reductase kinase immunoglobulin enhancer binding protein MMP8 protein, human neutrophil collagenase scleroprotein adult anatomical concepts Article cell culture cell stimulation controlled study disease severity enzyme linked immunosorbent assay extracellular trap flow cytometry human human tissue immunoblotting immunofluorescence microscopy immunohistochemistry immunopathology lung biopsy lung tuberculosis major clinical study matrix destruction neutrophil protein degradation protein expression real time polymerase chain reaction upregulation active transport chemistry cohort analysis drug effects enzymology host pathogen interaction immunology innate immunity lung metabolism Mycobacterium tuberculosis neutrophil neutrophil chemotaxis pathology phosphorylation physiology protein processing respiratory mucosa secretion (process) sputum Tuberculosis, Pulmonary Mycobacterium tuberculosis Active Transport, Cell Nucleus Adult AMP-Activated Protein Kinases Cells, Cultured Cohort Studies Enzyme Inhibitors Extracellular Matrix Proteins Host-Pathogen Interactions Humans Immunity, Innate Lung Matrix Metalloproteinase 8 Mycobacterium tuberculosis Neutrophil Infiltration Neutrophils NF-kappa B Phosphorylation Protein Processing, Post-Translational Proteolysis Respiratory Mucosa Sputum Tuberculosis, Pulmonary
spellingShingle	collagen type 1 gelatin gelatinase B hydroxymethylglutaryl coenzyme A reductase kinase myeloperoxidase neutrophil collagenase neutrophil gelatinase associated lipocalin phosphotransferase tissue inhibitor of metalloproteinase 1 tissue inhibitor of metalloproteinase 2 enzyme inhibitor hydroxymethylglutaryl coenzyme A reductase kinase immunoglobulin enhancer binding protein MMP8 protein, human neutrophil collagenase scleroprotein adult anatomical concepts Article cell culture cell stimulation controlled study disease severity enzyme linked immunosorbent assay extracellular trap flow cytometry human human tissue immunoblotting immunofluorescence microscopy immunohistochemistry immunopathology lung biopsy lung tuberculosis major clinical study matrix destruction neutrophil protein degradation protein expression real time polymerase chain reaction upregulation active transport chemistry cohort analysis drug effects enzymology host pathogen interaction immunology innate immunity lung metabolism Mycobacterium tuberculosis neutrophil neutrophil chemotaxis pathology phosphorylation physiology protein processing respiratory mucosa secretion (process) sputum Tuberculosis, Pulmonary Mycobacterium tuberculosis Active Transport, Cell Nucleus Adult AMP-Activated Protein Kinases Cells, Cultured Cohort Studies Enzyme Inhibitors Extracellular Matrix Proteins Host-Pathogen Interactions Humans Immunity, Innate Lung Matrix Metalloproteinase 8 Mycobacterium tuberculosis Neutrophil Infiltration Neutrophils NF-kappa B Phosphorylation Protein Processing, Post-Translational Proteolysis Respiratory Mucosa Sputum Tuberculosis, Pulmonary Ong C.W.M. Elkington P.T. Brilha S. Ugarte-Gil C. Tome-Esteban M.T. Tezera L.B. Pabisiak P.J. Moores R.C. Sathyamoorthy T. Patel V. Gilman R.H. Porter J.C. Friedland J.S. Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis
description	10.1371/journal.ppat.1004917
author2	MEDICINE
author_facet	MEDICINE Ong C.W.M. Elkington P.T. Brilha S. Ugarte-Gil C. Tome-Esteban M.T. Tezera L.B. Pabisiak P.J. Moores R.C. Sathyamoorthy T. Patel V. Gilman R.H. Porter J.C. Friedland J.S.
format	Article
author	Ong C.W.M. Elkington P.T. Brilha S. Ugarte-Gil C. Tome-Esteban M.T. Tezera L.B. Pabisiak P.J. Moores R.C. Sathyamoorthy T. Patel V. Gilman R.H. Porter J.C. Friedland J.S.
author_sort	Ong C.W.M.
title	Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis
title_short	Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis
title_full	Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis
title_fullStr	Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis
title_full_unstemmed	Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis
title_sort	neutrophil-derived mmp-8 drives ampk-dependent matrix destruction in human pulmonary tuberculosis
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161936
_version_	1821191693945274368

Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis

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