Inhibition of enterovirus 71 (EV-71) infections by a novel antiviral peptide derived from EV-71 capsid protein VP1

• Main Authors: Tan C.W., Chan Y.F., Sim K.M., Tan E.L., Poh C.L.
• Other Authors: PAEDIATRICS
• Format: Article
• Published: 2019
• Subjects: antivirus agent; arginine; lysine; protein VP1; SP40 peptide; SP40X peptide; unclassified drug; alanine; capsid protein; oligopeptide; amino acid substitution; animal cell; antiviral activity; article; cancer cell; concentration response; controlled study; Coxsackie virus A; drug mechanism; drug specificity; Enterovirus 71; Enterovirus infection; female; genotype; human; human cell; IC 50; in vitro study; nonhuman; nucleotide sequence; Poliomyelitis virus 1; rhabdomyosarcoma; structure activity relation; virus attachment; amino acid sequence; animal; cell proliferation; cell strain HT29; cell survival; Cercopithecus; chemical structure; chemistry; drug effect; Enterovirus; genetics; growth, development and aging; HeLa cell; molecular genetics; peptide library; protein conformation; protein secondary structure; sequence homology; synthesis; tumor cell line; Vero cell; virology; Human enterovirus 71; Human poliovirus 1; Miridae; Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Antiviral Agents; Capsid Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cercopithecus aethiops; Enterovirus A, Human; Enterovirus Infections; HeLa Cells; HT29 Cells; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Sequence Data; Oligopeptides; Peptide Library; Protein Conformation; Protein Structure, Secondary; Sequence Homology, Amino Acid; Vero Cells
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161985
• Institution: National University of Singapore

10.1371/journal.pone.0034589