Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: Implications for clinical translation

10.1371/journal.pone.0020226

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Main Authors:	McMillin D.W., Delmore J., Negri J., Ooi M., Klippel S., Miduturu C.V., Gray N.S., Richardson P.G., Anderson K.C., Kung A.L., Mitsiades C.S.
Other Authors:	MEDICINE
Format:	Article
Published:	2019
Subjects:	4 (8 cyclopentyl 7 ethyl 5,6,7,8 tetrahydro 5 methyl 6 oxo 2 pteridinylamino) 3 methoxy n (1 methyl 4 piperidinyl)benzamide polo like kinase caspase 3 cell cycle protein nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase oncoprotein polo like kinase 1 polo-like kinase 1 protein serine threonine kinase pteridine derivative animal experiment animal model article cell interaction controlled study drug mechanism enzyme activity enzyme inhibition human human cell in vitro study in vivo study mouse multiple myeloma nonhuman tumor microenvironment tumor xenograft bone cell cycle cell line cell survival coculture dose response drug antagonism drug effect drug screening IC 50 metabolism osteoclast pathology stroma cell time tumor cell line tumor volume Western blotting Blotting, Western Bone and Bones Caspase 3 Cell Cycle Cell Cycle Proteins Cell Line Cell Line, Tumor Cell Survival Coculture Techniques Dose-Response Relationship, Drug Humans Inhibitory Concentration 50 Multiple Myeloma Osteoclasts Poly(ADP-ribose) Polymerases Protein-Serine-Threonine Kinases Proto-Oncogene Proteins Pteridines Stromal Cells Time Factors Tumor Burden Tumor Microenvironment Xenograft Model Antitumor Assays
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/162044
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1620442024-05-08T09:51:25Z Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: Implications for clinical translation McMillin D.W. Delmore J. Negri J. Ooi M. Klippel S. Miduturu C.V. Gray N.S. Richardson P.G. Anderson K.C. Kung A.L. Mitsiades C.S. MEDICINE 4 (8 cyclopentyl 7 ethyl 5,6,7,8 tetrahydro 5 methyl 6 oxo 2 pteridinylamino) 3 methoxy n (1 methyl 4 piperidinyl)benzamide polo like kinase 4 (8 cyclopentyl 7 ethyl 5,6,7,8 tetrahydro 5 methyl 6 oxo 2 pteridinylamino) 3 methoxy n (1 methyl 4 piperidinyl)benzamide caspase 3 cell cycle protein nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase oncoprotein polo like kinase 1 polo-like kinase 1 protein serine threonine kinase pteridine derivative animal experiment animal model article cell interaction controlled study drug mechanism enzyme activity enzyme inhibition human human cell in vitro study in vivo study mouse multiple myeloma nonhuman tumor microenvironment tumor xenograft bone cell cycle cell line cell survival coculture dose response drug antagonism drug effect drug screening IC 50 metabolism osteoclast pathology stroma cell time tumor cell line tumor microenvironment tumor volume Western blotting Blotting, Western Bone and Bones Caspase 3 Cell Cycle Cell Cycle Proteins Cell Line Cell Line, Tumor Cell Survival Coculture Techniques Dose-Response Relationship, Drug Humans Inhibitory Concentration 50 Multiple Myeloma Osteoclasts Poly(ADP-ribose) Polymerases Protein-Serine-Threonine Kinases Proto-Oncogene Proteins Pteridines Stromal Cells Time Factors Tumor Burden Tumor Microenvironment Xenograft Model Antitumor Assays 10.1371/journal.pone.0020226 PLoS ONE 6 7 e20226 2019-11-11T08:39:46Z 2019-11-11T08:39:46Z 2011 Article McMillin D.W., Delmore J., Negri J., Ooi M., Klippel S., Miduturu C.V., Gray N.S., Richardson P.G., Anderson K.C., Kung A.L., Mitsiades C.S. (2011). Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: Implications for clinical translation. PLoS ONE 6 (7) : e20226. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0020226 19326203 https://scholarbank.nus.edu.sg/handle/10635/162044 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	4 (8 cyclopentyl 7 ethyl 5,6,7,8 tetrahydro 5 methyl 6 oxo 2 pteridinylamino) 3 methoxy n (1 methyl 4 piperidinyl)benzamide polo like kinase 4 (8 cyclopentyl 7 ethyl 5,6,7,8 tetrahydro 5 methyl 6 oxo 2 pteridinylamino) 3 methoxy n (1 methyl 4 piperidinyl)benzamide caspase 3 cell cycle protein nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase oncoprotein polo like kinase 1 polo-like kinase 1 protein serine threonine kinase pteridine derivative animal experiment animal model article cell interaction controlled study drug mechanism enzyme activity enzyme inhibition human human cell in vitro study in vivo study mouse multiple myeloma nonhuman tumor microenvironment tumor xenograft bone cell cycle cell line cell survival coculture dose response drug antagonism drug effect drug screening IC 50 metabolism osteoclast pathology stroma cell time tumor cell line tumor microenvironment tumor volume Western blotting Blotting, Western Bone and Bones Caspase 3 Cell Cycle Cell Cycle Proteins Cell Line Cell Line, Tumor Cell Survival Coculture Techniques Dose-Response Relationship, Drug Humans Inhibitory Concentration 50 Multiple Myeloma Osteoclasts Poly(ADP-ribose) Polymerases Protein-Serine-Threonine Kinases Proto-Oncogene Proteins Pteridines Stromal Cells Time Factors Tumor Burden Tumor Microenvironment Xenograft Model Antitumor Assays
spellingShingle	4 (8 cyclopentyl 7 ethyl 5,6,7,8 tetrahydro 5 methyl 6 oxo 2 pteridinylamino) 3 methoxy n (1 methyl 4 piperidinyl)benzamide polo like kinase 4 (8 cyclopentyl 7 ethyl 5,6,7,8 tetrahydro 5 methyl 6 oxo 2 pteridinylamino) 3 methoxy n (1 methyl 4 piperidinyl)benzamide caspase 3 cell cycle protein nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase oncoprotein polo like kinase 1 polo-like kinase 1 protein serine threonine kinase pteridine derivative animal experiment animal model article cell interaction controlled study drug mechanism enzyme activity enzyme inhibition human human cell in vitro study in vivo study mouse multiple myeloma nonhuman tumor microenvironment tumor xenograft bone cell cycle cell line cell survival coculture dose response drug antagonism drug effect drug screening IC 50 metabolism osteoclast pathology stroma cell time tumor cell line tumor microenvironment tumor volume Western blotting Blotting, Western Bone and Bones Caspase 3 Cell Cycle Cell Cycle Proteins Cell Line Cell Line, Tumor Cell Survival Coculture Techniques Dose-Response Relationship, Drug Humans Inhibitory Concentration 50 Multiple Myeloma Osteoclasts Poly(ADP-ribose) Polymerases Protein-Serine-Threonine Kinases Proto-Oncogene Proteins Pteridines Stromal Cells Time Factors Tumor Burden Tumor Microenvironment Xenograft Model Antitumor Assays McMillin D.W. Delmore J. Negri J. Ooi M. Klippel S. Miduturu C.V. Gray N.S. Richardson P.G. Anderson K.C. Kung A.L. Mitsiades C.S. Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: Implications for clinical translation
description	10.1371/journal.pone.0020226
author2	MEDICINE
author_facet	MEDICINE McMillin D.W. Delmore J. Negri J. Ooi M. Klippel S. Miduturu C.V. Gray N.S. Richardson P.G. Anderson K.C. Kung A.L. Mitsiades C.S.
format	Article
author	McMillin D.W. Delmore J. Negri J. Ooi M. Klippel S. Miduturu C.V. Gray N.S. Richardson P.G. Anderson K.C. Kung A.L. Mitsiades C.S.
author_sort	McMillin D.W.
title	Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: Implications for clinical translation
title_short	Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: Implications for clinical translation
title_full	Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: Implications for clinical translation
title_fullStr	Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: Implications for clinical translation
title_full_unstemmed	Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: Implications for clinical translation
title_sort	microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: implications for clinical translation
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/162044
_version_	1800913832199061504

Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: Implications for clinical translation

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