Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: Implications for clinical translation

• Main Authors: McMillin D.W., Delmore J., Negri J., Ooi M., Klippel S., Miduturu C.V., Gray N.S., Richardson P.G., Anderson K.C., Kung A.L., Mitsiades C.S.
• Other Authors: MEDICINE
• Format: Article
• Published: 2019
• Subjects: 4 (8 cyclopentyl 7 ethyl 5,6,7,8 tetrahydro 5 methyl 6 oxo 2 pteridinylamino) 3 methoxy n (1 methyl 4 piperidinyl)benzamide; polo like kinase; caspase 3; cell cycle protein; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; oncoprotein; polo like kinase 1; polo-like kinase 1; protein serine threonine kinase; pteridine derivative; animal experiment; animal model; article; cell interaction; controlled study; drug mechanism; enzyme activity; enzyme inhibition; human; human cell; in vitro study; in vivo study; mouse; multiple myeloma; nonhuman; tumor microenvironment; tumor xenograft; bone; cell cycle; cell line; cell survival; coculture; dose response; drug antagonism; drug effect; drug screening; IC 50; metabolism; osteoclast; pathology; stroma cell; time; tumor cell line; tumor volume; Western blotting; Blotting, Western; Bone and Bones; Caspase 3; Cell Cycle; Cell Cycle Proteins; Cell Line; Cell Line, Tumor; Cell Survival; Coculture Techniques; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Multiple Myeloma; Osteoclasts; Poly(ADP-ribose) Polymerases; Protein-Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Stromal Cells; Time Factors; Tumor Burden; Tumor Microenvironment; Xenograft Model Antitumor Assays
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/162044
• Institution: National University of Singapore

10.1371/journal.pone.0020226