TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter

• Main Authors: Rajagopalan D., Pandey A.K., Xiuzhen M.C., Lee K.K., Hora S., Zhang Y., Chua B.H., Kwok H.S., Bhatia S.S., Deng L.W., Tenen D.G., Kappei D., Jha S.
• Other Authors: CANCER SCIENCE INSTITUTE OF SINGAPORE
• Format: Article
• Published: Public Library of Science 2020
• Subjects: oncoprotein; telomerase; telomerase reverse transcriptase; transactivator protein; transactivator protein 60; transcription factor Sp1; unclassified drug; histone acetyltransferase; KAT5 protein, human; Sp1 protein, human; TERT protein, human; tumor protein; acetylation; Article; catalysis; cell immortalization; chromatin immunoprecipitation; colony formation; controlled study; down regulation; enzyme active site; gene overexpression; genetic transfection; growth inhibition; human; human cell; luciferase assay; mass spectrometry; molecular biology; promoter region; protein expression; real time polymerase chain reaction; RNA isolation; site directed mutagenesis; telomeric repeat amplification protocol; transient transfection; uterine cervix cancer; virus infection; Wart virus; Western blotting; biosynthesis; DNA responsive element; female; gene expression regulation; genetics; HeLa cell line; metabolism; uterine cervix tumor; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; HeLa Cells; Histone Acetyltransferases; Humans; Neoplasm Proteins; Response Elements; Sp1 Transcription Factor; Telomerase; Uterine Cervical Neoplasms
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165368
• Institution: National University of Singapore

10.1371/journal.ppat.1006681