TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter

10.1371/journal.ppat.1006681

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Main Authors:	Rajagopalan D., Pandey A.K., Xiuzhen M.C., Lee K.K., Hora S., Zhang Y., Chua B.H., Kwok H.S., Bhatia S.S., Deng L.W., Tenen D.G., Kappei D., Jha S.
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Article
Published:	Public Library of Science 2020
Subjects:	oncoprotein telomerase telomerase reverse transcriptase transactivator protein transactivator protein 60 transcription factor Sp1 unclassified drug histone acetyltransferase KAT5 protein, human Sp1 protein, human TERT protein, human tumor protein acetylation Article catalysis cell immortalization chromatin immunoprecipitation colony formation controlled study down regulation enzyme active site gene overexpression genetic transfection growth inhibition human human cell luciferase assay mass spectrometry molecular biology promoter region protein expression real time polymerase chain reaction RNA isolation site directed mutagenesis telomeric repeat amplification protocol transient transfection uterine cervix cancer virus infection Wart virus Western blotting biosynthesis DNA responsive element female gene expression regulation genetics HeLa cell line metabolism uterine cervix tumor Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic HeLa Cells Histone Acetyltransferases Humans Neoplasm Proteins Response Elements Sp1 Transcription Factor Telomerase Uterine Cervical Neoplasms
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/165368
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1653682024-05-08T09:52:04Z TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter Rajagopalan D. Pandey A.K. Xiuzhen M.C. Lee K.K. Hora S. Zhang Y. Chua B.H. Kwok H.S. Bhatia S.S. Deng L.W. Tenen D.G. Kappei D. Jha S. CANCER SCIENCE INSTITUTE OF SINGAPORE BIOCHEMISTRY MEDICINE oncoprotein telomerase telomerase reverse transcriptase transactivator protein transactivator protein 60 transcription factor Sp1 unclassified drug histone acetyltransferase KAT5 protein, human Sp1 protein, human telomerase TERT protein, human transcription factor Sp1 tumor protein acetylation Article catalysis cell immortalization chromatin immunoprecipitation colony formation controlled study down regulation enzyme active site gene overexpression genetic transfection growth inhibition human human cell luciferase assay mass spectrometry molecular biology promoter region protein expression real time polymerase chain reaction RNA isolation site directed mutagenesis telomeric repeat amplification protocol transient transfection uterine cervix cancer virus infection Wart virus Western blotting biosynthesis DNA responsive element female gene expression regulation genetics HeLa cell line metabolism uterine cervix tumor Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic HeLa Cells Histone Acetyltransferases Humans Neoplasm Proteins Response Elements Sp1 Transcription Factor Telomerase Uterine Cervical Neoplasms 10.1371/journal.ppat.1006681 PLoS Pathogens 13 10 e1006681 2020-03-13T05:21:37Z 2020-03-13T05:21:37Z 2017 Article Rajagopalan D., Pandey A.K., Xiuzhen M.C., Lee K.K., Hora S., Zhang Y., Chua B.H., Kwok H.S., Bhatia S.S., Deng L.W., Tenen D.G., Kappei D., Jha S. (2017). TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter. PLoS Pathogens 13 (10) : e1006681. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.ppat.1006681 15537366 https://scholarbank.nus.edu.sg/handle/10635/165368 Public Library of Science Unpaywall 20200320
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	oncoprotein telomerase telomerase reverse transcriptase transactivator protein transactivator protein 60 transcription factor Sp1 unclassified drug histone acetyltransferase KAT5 protein, human Sp1 protein, human telomerase TERT protein, human transcription factor Sp1 tumor protein acetylation Article catalysis cell immortalization chromatin immunoprecipitation colony formation controlled study down regulation enzyme active site gene overexpression genetic transfection growth inhibition human human cell luciferase assay mass spectrometry molecular biology promoter region protein expression real time polymerase chain reaction RNA isolation site directed mutagenesis telomeric repeat amplification protocol transient transfection uterine cervix cancer virus infection Wart virus Western blotting biosynthesis DNA responsive element female gene expression regulation genetics HeLa cell line metabolism uterine cervix tumor Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic HeLa Cells Histone Acetyltransferases Humans Neoplasm Proteins Response Elements Sp1 Transcription Factor Telomerase Uterine Cervical Neoplasms
spellingShingle	oncoprotein telomerase telomerase reverse transcriptase transactivator protein transactivator protein 60 transcription factor Sp1 unclassified drug histone acetyltransferase KAT5 protein, human Sp1 protein, human telomerase TERT protein, human transcription factor Sp1 tumor protein acetylation Article catalysis cell immortalization chromatin immunoprecipitation colony formation controlled study down regulation enzyme active site gene overexpression genetic transfection growth inhibition human human cell luciferase assay mass spectrometry molecular biology promoter region protein expression real time polymerase chain reaction RNA isolation site directed mutagenesis telomeric repeat amplification protocol transient transfection uterine cervix cancer virus infection Wart virus Western blotting biosynthesis DNA responsive element female gene expression regulation genetics HeLa cell line metabolism uterine cervix tumor Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic HeLa Cells Histone Acetyltransferases Humans Neoplasm Proteins Response Elements Sp1 Transcription Factor Telomerase Uterine Cervical Neoplasms Rajagopalan D. Pandey A.K. Xiuzhen M.C. Lee K.K. Hora S. Zhang Y. Chua B.H. Kwok H.S. Bhatia S.S. Deng L.W. Tenen D.G. Kappei D. Jha S. TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter
description	10.1371/journal.ppat.1006681
author2	CANCER SCIENCE INSTITUTE OF SINGAPORE
author_facet	CANCER SCIENCE INSTITUTE OF SINGAPORE Rajagopalan D. Pandey A.K. Xiuzhen M.C. Lee K.K. Hora S. Zhang Y. Chua B.H. Kwok H.S. Bhatia S.S. Deng L.W. Tenen D.G. Kappei D. Jha S.
format	Article
author	Rajagopalan D. Pandey A.K. Xiuzhen M.C. Lee K.K. Hora S. Zhang Y. Chua B.H. Kwok H.S. Bhatia S.S. Deng L.W. Tenen D.G. Kappei D. Jha S.
author_sort	Rajagopalan D.
title	TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter
title_short	TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter
title_full	TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter
title_fullStr	TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter
title_full_unstemmed	TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter
title_sort	tip60 represses telomerase expression by inhibiting sp1 binding to the tert promoter
publisher	Public Library of Science
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/165368
_version_	1800913915497938944

TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter

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