Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells

• Main Authors: Pothlichet J., Meunier I., Davis B.K., Ting J.P.-Y., Skamene E., von Messling V., Vidal S.M.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Public Library of Science 2020
• Subjects: cryopyrin; inflammasome; interferon; interleukin 1beta; interleukin 1beta converting enzyme; retinoic acid inducible protein I; small interfering RNA; toll like receptor 3; virulence factor; animal cell; animal experiment; article; controlled study; enzyme linked immunosorbent assay; ferret; gene silencing; human; human cell; immunoblotting; Influenza virus A; lung alveolus epithelium; macrophage; male; nonhuman; reverse transcription polymerase chain reaction; signal transduction; Adaptor Proteins, Signal Transducing; Animals; Carrier Proteins; Caspase 1; Cells, Cultured; Cytoskeletal Proteins; DEAD-box RNA Helicases; Epithelial Cells; Ferrets; HEK293 Cells; Humans; Inflammasomes; Influenza A Virus, H1N1 Subtype; Interferon-beta; Lung; Macrophages; Male; Respiratory Mucosa; RNA Interference; Signal Transduction; Toll-Like Receptor 3; Transcription Factors; Ubiquitin-Protein Ligases; Viral Nonstructural Proteins; Influenza A virus; Mustela
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165405
• Institution: National University of Singapore

10.1371/journal.ppat.1003256