A novel Ribozyme-Based prophylaxis inhibits influenza a virus replication and protects from severe disease

• Main Authors: Motard J., Rouxel R., Paun A., von Messling V., Bisaillon M., Perreault J.-P.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Public Library of Science 2020
• Subjects: messenger RNA; nucleic acid; protein SOFA; ribozyme; unclassified drug; virus RNA; antivirus agent; nucleoprotein; recombinant protein; animal cell; animal experiment; animal model; antiviral activity; article; controlled study; disease severity; drug efficacy; enzyme engineering; female; Hepatitis delta virus; human; human cell; influenza A; Influenza virus A; mouse; nonhuman; nucleotide sequence; protein targeting; RNA cleavage; virus replication; animal; biocatalysis; cell strain HEK293; drug effect; enzymology; genetics; influenza; Influenza virus A H1N1; metabolism; physiology; virology; Influenza A virus; Mus; Animals; Antiviral Agents; Base Sequence; Biocatalysis; Female; HEK293 Cells; Hepatitis Delta Virus; Humans; Influenza A Virus, H1N1 Subtype; Influenza, Human; Mice; Nucleoproteins; Recombinant Proteins; RNA, Catalytic; RNA, Messenger; RNA, Viral; Virus Replication
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165585
• Institution: National University of Singapore

10.1371/journal.pone.0027327