A novel Ribozyme-Based prophylaxis inhibits influenza a virus replication and protects from severe disease

10.1371/journal.pone.0027327

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Main Authors:	Motard J., Rouxel R., Paun A., von Messling V., Bisaillon M., Perreault J.-P.
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	Public Library of Science 2020
Subjects:	messenger RNA nucleic acid protein SOFA ribozyme unclassified drug virus RNA antivirus agent nucleoprotein recombinant protein animal cell animal experiment animal model antiviral activity article controlled study disease severity drug efficacy enzyme engineering female Hepatitis delta virus human human cell influenza A Influenza virus A mouse nonhuman nucleotide sequence protein targeting RNA cleavage virus replication animal biocatalysis cell strain HEK293 drug effect enzymology genetics influenza Influenza virus A H1N1 metabolism physiology virology Influenza A virus Mus Animals Antiviral Agents Base Sequence Biocatalysis Female HEK293 Cells Hepatitis Delta Virus Humans Influenza A Virus, H1N1 Subtype Influenza, Human Mice Nucleoproteins Recombinant Proteins RNA, Catalytic RNA, Messenger RNA, Viral Virus Replication
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/165585
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Institution:	National University of Singapore

id	sg-nus-scholar.10635-165585
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spelling	sg-nus-scholar.10635-1655852024-11-08T20:05:07Z A novel Ribozyme-Based prophylaxis inhibits influenza a virus replication and protects from severe disease Motard J. Rouxel R. Paun A. von Messling V. Bisaillon M. Perreault J.-P. DUKE-NUS MEDICAL SCHOOL messenger RNA nucleic acid protein SOFA ribozyme unclassified drug virus RNA antivirus agent messenger RNA nucleoprotein recombinant protein ribozyme virus RNA animal cell animal experiment animal model antiviral activity article controlled study disease severity drug efficacy enzyme engineering female Hepatitis delta virus human human cell influenza A Influenza virus A mouse nonhuman nucleotide sequence protein targeting RNA cleavage virus replication animal biocatalysis cell strain HEK293 drug effect enzymology genetics influenza Influenza virus A H1N1 metabolism physiology virology virus replication Influenza A virus Mus Animals Antiviral Agents Base Sequence Biocatalysis Female HEK293 Cells Hepatitis Delta Virus Humans Influenza A Virus, H1N1 Subtype Influenza, Human Mice Nucleoproteins Recombinant Proteins RNA, Catalytic RNA, Messenger RNA, Viral Virus Replication 10.1371/journal.pone.0027327 PLoS ONE 6 11 e27327 2020-03-18T05:48:36Z 2020-03-18T05:48:36Z 2011 Article Motard J., Rouxel R., Paun A., von Messling V., Bisaillon M., Perreault J.-P. (2011). A novel Ribozyme-Based prophylaxis inhibits influenza a virus replication and protects from severe disease. PLoS ONE 6 (11) : e27327. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0027327 19326203 https://scholarbank.nus.edu.sg/handle/10635/165585 Public Library of Science Unpaywall 20200320
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	messenger RNA nucleic acid protein SOFA ribozyme unclassified drug virus RNA antivirus agent messenger RNA nucleoprotein recombinant protein ribozyme virus RNA animal cell animal experiment animal model antiviral activity article controlled study disease severity drug efficacy enzyme engineering female Hepatitis delta virus human human cell influenza A Influenza virus A mouse nonhuman nucleotide sequence protein targeting RNA cleavage virus replication animal biocatalysis cell strain HEK293 drug effect enzymology genetics influenza Influenza virus A H1N1 metabolism physiology virology virus replication Influenza A virus Mus Animals Antiviral Agents Base Sequence Biocatalysis Female HEK293 Cells Hepatitis Delta Virus Humans Influenza A Virus, H1N1 Subtype Influenza, Human Mice Nucleoproteins Recombinant Proteins RNA, Catalytic RNA, Messenger RNA, Viral Virus Replication
spellingShingle	messenger RNA nucleic acid protein SOFA ribozyme unclassified drug virus RNA antivirus agent messenger RNA nucleoprotein recombinant protein ribozyme virus RNA animal cell animal experiment animal model antiviral activity article controlled study disease severity drug efficacy enzyme engineering female Hepatitis delta virus human human cell influenza A Influenza virus A mouse nonhuman nucleotide sequence protein targeting RNA cleavage virus replication animal biocatalysis cell strain HEK293 drug effect enzymology genetics influenza Influenza virus A H1N1 metabolism physiology virology virus replication Influenza A virus Mus Animals Antiviral Agents Base Sequence Biocatalysis Female HEK293 Cells Hepatitis Delta Virus Humans Influenza A Virus, H1N1 Subtype Influenza, Human Mice Nucleoproteins Recombinant Proteins RNA, Catalytic RNA, Messenger RNA, Viral Virus Replication Motard J. Rouxel R. Paun A. von Messling V. Bisaillon M. Perreault J.-P. A novel Ribozyme-Based prophylaxis inhibits influenza a virus replication and protects from severe disease
description	10.1371/journal.pone.0027327
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Motard J. Rouxel R. Paun A. von Messling V. Bisaillon M. Perreault J.-P.
format	Article
author	Motard J. Rouxel R. Paun A. von Messling V. Bisaillon M. Perreault J.-P.
author_sort	Motard J.
title	A novel Ribozyme-Based prophylaxis inhibits influenza a virus replication and protects from severe disease
title_short	A novel Ribozyme-Based prophylaxis inhibits influenza a virus replication and protects from severe disease
title_full	A novel Ribozyme-Based prophylaxis inhibits influenza a virus replication and protects from severe disease
title_fullStr	A novel Ribozyme-Based prophylaxis inhibits influenza a virus replication and protects from severe disease
title_full_unstemmed	A novel Ribozyme-Based prophylaxis inhibits influenza a virus replication and protects from severe disease
title_sort	novel ribozyme-based prophylaxis inhibits influenza a virus replication and protects from severe disease
publisher	Public Library of Science
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/165585
_version_	1821185986321711104

A novel Ribozyme-Based prophylaxis inhibits influenza a virus replication and protects from severe disease

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