The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription

• Main Authors: Morin B., Coutard B., Lelke M., Ferron F., Kerber R., Jamal S., Frangeul A., Baronti C., Charrel R., de Lamballerie X., Vonrhein C., Lescar J., Bricogne G., Günther S., Canard B.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Public Library of Science 2020
• Subjects: arenavirus L protein; messenger RNA; unclassified drug; virus protein; amino terminal sequence; Arenavirus; article; controlled study; crystal structure; enzyme active site; enzyme activity; Lymphocytic choriomeningitis virus; mutagenesis; mutational analysis; nonhuman; protein cross linking; replicon; RNA binding; RNA replication; RNA transcription; virus characterization; Bunyaviridae; Catalytic Domain; Crystallization; Crystallography, X-Ray; Endonucleases; Endoribonucleases; Models, Molecular; Mutagenesis; Orthomyxoviridae; Protein Structure, Tertiary; RNA, Messenger; RNA, Viral; Transcription, Genetic; Arenaviridae
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165417
• Institution: National University of Singapore

10.1371/journal.ppat.1001038