Oxidative stress-induced glomerular mineralocorticoid receptor activation limits the benefit of salt reduction in Dahl salt-sensitive rats

• Main Authors: Kitada K., Nakano D., Liu Y., Fujisawa Y., Hitomi H., Shibayama Y., Shibata H., Nagai Y., Mori H., Masaki T., Kobori H., Nishiyama A.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Public Library of Science 2020
• Subjects: eplerenone; hydroethidine; mineralocorticoid receptor; paraquat; protein p22; protein p22phox; serum and glucocorticoid regulated kinase 1; tempol; unclassified drug; animal cell; animal experiment; animal tissue; article; blood pressure regulation; controlled study; Dahl salt sensitive rat; genetic transcription; glomerulus; high sodium intake; kidney injury; male; mesangium cell; nonhuman; oxidative stress; podocyte; protein function; proteinuria; receptor activation; sodium restriction; tissue level; Adrenalectomy; Aldosterone; Animals; Biological Markers; Blood Pressure; Cyclic N-Oxides; Ethidium; Feeding Behavior; Genes, Reporter; Immediate-Early Proteins; Kidney Glomerulus; Luciferases; Male; Mesangial Cells; Mice; Oxidative Stress; Podocytes; Protein-Serine-Threonine Kinases; Proteinuria; Rats; Rats, Inbred Dahl; Receptors, Mineralocorticoid; Sodium Chloride, Dietary; Sodium-Hydrogen Antiporter; Spin Labels; Systole; Time Factors; Rattus
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165569
• Institution: National University of Singapore

10.1371/journal.pone.0041896