VapC toxins from Mycobacterium tuberculosis are ribonucleases that differentially inhibit growth and are neutralized by cognate vapB antitoxins

• Main Authors: Ahidjo B.A., Kuhnert D., McKenzie J.L., Machowski E.E., Gordhan B.G., Arcus V., Abrahams G.L., Mizrahi V.
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: Public Library of Science 2020
• Subjects: antitoxin; bacterial toxin; ribonuclease; tetracycline; unclassified drug; vapB toxin; vapC toxin; bacterial protein; article; bacterial gene; bacterial growth; controlled study; enzyme activity; gene deletion; gene expression regulation; gene function; gene locus; gene overexpression; genetic selection; growth inhibition; Mycobacterium smegmatis; Mycobacterium tuberculosis; nonhuman; operon; phenotype; promoter region; protein expression; protein function; protein protein interaction; toxin analysis; genetics; growth, development and aging; metabolism; physiology; Antitoxins; Bacterial Proteins; Gene Expression Regulation, Bacterial; Ribonucleases
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165590
• Institution: National University of Singapore

10.1371/journal.pone.0021738