Absence of leucine zipper in the natural FOXP3Delta2Delta7 isoform does not affect dimerization but abrogates suppressive capacity

• Main Authors: Mailer R.K.W., Falk K., Rötzschke O.
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: Public Library of Science 2020
• Subjects: cytotoxic T lymphocyte antigen 4; immunoglobulin enhancer binding protein; interleukin 2 receptor alpha; isoprotein; leucine zipper protein; transcription factor FOXP3; transcription factor NFAT; transcription factor RUNX1; forkhead transcription factor; FOXP3 protein, human; primer DNA; RUNX1 protein, human; animal cell; animal experiment; article; cancer cell; carcinogenesis; CD4+ T lymphocyte; cell function; controlled study; dimerization; exon; gene mutation; gene repression; gene transfer; genetic transcription; human; human cell; immunoprecipitation; IPEX syndrome; mouse; nonhuman; phenotype; protein binding; protein expression; protein function; protein interaction; protein localization; regulatory T lymphocyte; reporter gene; Retrovirus; animal; Bagg albino mouse; cell fractionation; chemistry; genetics; immunology; metabolism; nucleotide sequence; physiology; reverse transcription polymerase chain reaction; Mus; Animals; Base Sequence; Core Binding Factor Alpha 2 Subunit; Dimerization; DNA Primers; Exons; Forkhead Transcription Factors; Humans; Leucine Zippers; Mice; Mice, Inbred BALB C; NF-kappa B; NFATC Transcription Factors; Protein Binding; Protein Isoforms; Reverse Transcriptase Polymerase Chain Reaction; Subcellular Fractions; T-Lymphocytes, Regulatory; Transcription, Genetic
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165604
• Institution: National University of Singapore

10.1371/journal.pone.0006104