Targeting YAP/TAZ-TEAD protein-protein interactions using fragment-based and computational modeling approaches

• Main Authors: Kaan H.Y.K., Sim A.Y.L., Tan S.K.J., Verma C., Song H.
• Other Authors: BIOLOGY (NU)
• Format: Article
• Published: Public Library of Science 2020
• Subjects: phenylalanine; transcription factor; transcription factor TAZ; transcription factor TEAD; transcription factor YAP; unclassified drug; ligand; protein binding; Article; binding site; cancer therapy; cell proliferation; complex formation; controlled study; genetic transcription; Hippo signaling pathway; human; human cell; protein protein interaction; signal transduction; structure activity relation; X ray crystallography; animal; calorimetry; chemistry; computer simulation; metabolism; mouse; Animals; Calorimetry; Computer Simulation; Crystallography, X-Ray; Humans; Ligands; Mice; Protein Binding; Structure-Activity Relationship; Transcription Factors
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165793
• Institution: National University of Singapore

10.1371/journal.pone.0178381