Neutralization of antibody-enhanced dengue infection by VIS513, a pan serotype reactive monoclonal antibody targeting domain III of the dengue E protein

10.1371/journal.pntd.0006209

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Main Authors:	Budigi Y., Ong E.Z., Robinson L.N., Ong L.C., Rowley K.J., Winnett A., Tan H.C., Hobbie S., Shriver Z., Babcock G.J., Alonso S., Ooi E.E.
Other Authors:	MICROBIOLOGY AND IMMUNOLOGY
Format:	Article
Published:	Public Library of Science 2020
Subjects:	dengue E protein monoclonal antibody neutralizing antibody unclassified drug viral protein vis513 antiserum epitope recombinant protein virus antibody virus antigen virus envelope protein animal cell animal experiment animal model Article C6/36 cell line controlled study dengue Dengue virus Dengue virus 1 Dengue virus 2 Dengue virus 3 Dengue virus 4 female gene mutation immobilized metal affinity chromatography male mouse mutational analysis nonhuman polymerase chain reaction reverse transcription polymerase chain reaction serotype virus load virus neutralization virus strain animal blood cell line chemistry Chlorocebus aethiops cross reaction disease model genetics human immunology immunotherapy in vitro study mutation pathogenicity protein conformation serodiagnosis structural model THP-1 cell line Vero cell line viral plaque assay Animals Antibodies, Monoclonal Antibodies, Neutralizing Antibodies, Viral Antigens, Viral Cell Line Cercopithecus aethiops Cross Reactions Dengue Dengue Virus Disease Models, Animal Epitopes Female Humans Immune Sera Immunotherapy In Vitro Techniques Mice Models, Structural Mutation Neutralization Tests Protein Conformation Recombinant Proteins Serogroup THP-1 Cells Vero Cells Viral Envelope Proteins Viral Plaque Assay
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/165622
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1656222024-11-14T15:45:05Z Neutralization of antibody-enhanced dengue infection by VIS513, a pan serotype reactive monoclonal antibody targeting domain III of the dengue E protein Budigi Y. Ong E.Z. Robinson L.N. Ong L.C. Rowley K.J. Winnett A. Tan H.C. Hobbie S. Shriver Z. Babcock G.J. Alonso S. Ooi E.E. MICROBIOLOGY AND IMMUNOLOGY DUKE-NUS MEDICAL SCHOOL dengue E protein monoclonal antibody neutralizing antibody unclassified drug viral protein vis513 antiserum epitope monoclonal antibody recombinant protein virus antibody virus antigen virus envelope protein animal cell animal experiment animal model Article C6/36 cell line controlled study dengue Dengue virus Dengue virus 1 Dengue virus 2 Dengue virus 3 Dengue virus 4 female gene mutation immobilized metal affinity chromatography male mouse mutational analysis nonhuman polymerase chain reaction reverse transcription polymerase chain reaction serotype virus load virus neutralization virus strain animal blood cell line chemistry Chlorocebus aethiops cross reaction dengue Dengue virus disease model genetics human immunology immunotherapy in vitro study mutation pathogenicity protein conformation serodiagnosis structural model THP-1 cell line Vero cell line viral plaque assay Animals Antibodies, Monoclonal Antibodies, Neutralizing Antibodies, Viral Antigens, Viral Cell Line Cercopithecus aethiops Cross Reactions Dengue Dengue Virus Disease Models, Animal Epitopes Female Humans Immune Sera Immunotherapy In Vitro Techniques Mice Models, Structural Mutation Neutralization Tests Protein Conformation Recombinant Proteins Serogroup THP-1 Cells Vero Cells Viral Envelope Proteins Viral Plaque Assay 10.1371/journal.pntd.0006209 PLoS Neglected Tropical Diseases 12 2 e0006209 2020-03-18T05:55:18Z 2020-03-18T05:55:18Z 2018 Article Budigi Y., Ong E.Z., Robinson L.N., Ong L.C., Rowley K.J., Winnett A., Tan H.C., Hobbie S., Shriver Z., Babcock G.J., Alonso S., Ooi E.E. (2018). Neutralization of antibody-enhanced dengue infection by VIS513, a pan serotype reactive monoclonal antibody targeting domain III of the dengue E protein. PLoS Neglected Tropical Diseases 12 (2) : e0006209. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pntd.0006209 19352727 https://scholarbank.nus.edu.sg/handle/10635/165622 Public Library of Science Unpaywall 20200320
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	dengue E protein monoclonal antibody neutralizing antibody unclassified drug viral protein vis513 antiserum epitope monoclonal antibody recombinant protein virus antibody virus antigen virus envelope protein animal cell animal experiment animal model Article C6/36 cell line controlled study dengue Dengue virus Dengue virus 1 Dengue virus 2 Dengue virus 3 Dengue virus 4 female gene mutation immobilized metal affinity chromatography male mouse mutational analysis nonhuman polymerase chain reaction reverse transcription polymerase chain reaction serotype virus load virus neutralization virus strain animal blood cell line chemistry Chlorocebus aethiops cross reaction dengue Dengue virus disease model genetics human immunology immunotherapy in vitro study mutation pathogenicity protein conformation serodiagnosis structural model THP-1 cell line Vero cell line viral plaque assay Animals Antibodies, Monoclonal Antibodies, Neutralizing Antibodies, Viral Antigens, Viral Cell Line Cercopithecus aethiops Cross Reactions Dengue Dengue Virus Disease Models, Animal Epitopes Female Humans Immune Sera Immunotherapy In Vitro Techniques Mice Models, Structural Mutation Neutralization Tests Protein Conformation Recombinant Proteins Serogroup THP-1 Cells Vero Cells Viral Envelope Proteins Viral Plaque Assay
spellingShingle	dengue E protein monoclonal antibody neutralizing antibody unclassified drug viral protein vis513 antiserum epitope monoclonal antibody recombinant protein virus antibody virus antigen virus envelope protein animal cell animal experiment animal model Article C6/36 cell line controlled study dengue Dengue virus Dengue virus 1 Dengue virus 2 Dengue virus 3 Dengue virus 4 female gene mutation immobilized metal affinity chromatography male mouse mutational analysis nonhuman polymerase chain reaction reverse transcription polymerase chain reaction serotype virus load virus neutralization virus strain animal blood cell line chemistry Chlorocebus aethiops cross reaction dengue Dengue virus disease model genetics human immunology immunotherapy in vitro study mutation pathogenicity protein conformation serodiagnosis structural model THP-1 cell line Vero cell line viral plaque assay Animals Antibodies, Monoclonal Antibodies, Neutralizing Antibodies, Viral Antigens, Viral Cell Line Cercopithecus aethiops Cross Reactions Dengue Dengue Virus Disease Models, Animal Epitopes Female Humans Immune Sera Immunotherapy In Vitro Techniques Mice Models, Structural Mutation Neutralization Tests Protein Conformation Recombinant Proteins Serogroup THP-1 Cells Vero Cells Viral Envelope Proteins Viral Plaque Assay Budigi Y. Ong E.Z. Robinson L.N. Ong L.C. Rowley K.J. Winnett A. Tan H.C. Hobbie S. Shriver Z. Babcock G.J. Alonso S. Ooi E.E. Neutralization of antibody-enhanced dengue infection by VIS513, a pan serotype reactive monoclonal antibody targeting domain III of the dengue E protein
description	10.1371/journal.pntd.0006209
author2	MICROBIOLOGY AND IMMUNOLOGY
author_facet	MICROBIOLOGY AND IMMUNOLOGY Budigi Y. Ong E.Z. Robinson L.N. Ong L.C. Rowley K.J. Winnett A. Tan H.C. Hobbie S. Shriver Z. Babcock G.J. Alonso S. Ooi E.E.
format	Article
author	Budigi Y. Ong E.Z. Robinson L.N. Ong L.C. Rowley K.J. Winnett A. Tan H.C. Hobbie S. Shriver Z. Babcock G.J. Alonso S. Ooi E.E.
author_sort	Budigi Y.
title	Neutralization of antibody-enhanced dengue infection by VIS513, a pan serotype reactive monoclonal antibody targeting domain III of the dengue E protein
title_short	Neutralization of antibody-enhanced dengue infection by VIS513, a pan serotype reactive monoclonal antibody targeting domain III of the dengue E protein
title_full	Neutralization of antibody-enhanced dengue infection by VIS513, a pan serotype reactive monoclonal antibody targeting domain III of the dengue E protein
title_fullStr	Neutralization of antibody-enhanced dengue infection by VIS513, a pan serotype reactive monoclonal antibody targeting domain III of the dengue E protein
title_full_unstemmed	Neutralization of antibody-enhanced dengue infection by VIS513, a pan serotype reactive monoclonal antibody targeting domain III of the dengue E protein
title_sort	neutralization of antibody-enhanced dengue infection by vis513, a pan serotype reactive monoclonal antibody targeting domain iii of the dengue e protein
publisher	Public Library of Science
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/165622
_version_	1821201594913390592

Neutralization of antibody-enhanced dengue infection by VIS513, a pan serotype reactive monoclonal antibody targeting domain III of the dengue E protein

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