Neutralization of antibody-enhanced dengue infection by VIS513, a pan serotype reactive monoclonal antibody targeting domain III of the dengue E protein

• Main Authors: Budigi Y., Ong E.Z., Robinson L.N., Ong L.C., Rowley K.J., Winnett A., Tan H.C., Hobbie S., Shriver Z., Babcock G.J., Alonso S., Ooi E.E.
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: Public Library of Science 2020
• Subjects: dengue E protein; monoclonal antibody; neutralizing antibody; unclassified drug; viral protein; vis513; antiserum; epitope; recombinant protein; virus antibody; virus antigen; virus envelope protein; animal cell; animal experiment; animal model; Article; C6/36 cell line; controlled study; dengue; Dengue virus; Dengue virus 1; Dengue virus 2; Dengue virus 3; Dengue virus 4; female; gene mutation; immobilized metal affinity chromatography; male; mouse; mutational analysis; nonhuman; polymerase chain reaction; reverse transcription polymerase chain reaction; serotype; virus load; virus neutralization; virus strain; animal; blood; cell line; chemistry; Chlorocebus aethiops; cross reaction; disease model; genetics; human; immunology; immunotherapy; in vitro study; mutation; pathogenicity; protein conformation; serodiagnosis; structural model; THP-1 cell line; Vero cell line; viral plaque assay; Animals; Antibodies, Monoclonal; Antibodies, Neutralizing; Antibodies, Viral; Antigens, Viral; Cell Line; Cercopithecus aethiops; Cross Reactions; Dengue; Dengue Virus; Disease Models, Animal; Epitopes; Female; Humans; Immune Sera; Immunotherapy; In Vitro Techniques; Mice; Models, Structural; Mutation; Neutralization Tests; Protein Conformation; Recombinant Proteins; Serogroup; THP-1 Cells; Vero Cells; Viral Envelope Proteins; Viral Plaque Assay
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165622
• Institution: National University of Singapore

10.1371/journal.pntd.0006209