Understanding zika virus stability and developing a chimeric vaccine through functional analysis

• Main Authors: Xie, X, Yang, Y, Muruato, A.E, Zou, J, Shan, C, Nunes, B.T.D, Medeiros, D.B.A, Vasconcelos, P.F.C, Weaver, S.C, Rossi, S.L, Shi, P.-Y
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: American Society for Microbiology 2020
• Subjects: neutralizing antibody; live vaccine; prM protein, Flavivirus; virus envelope protein; virus vaccine; animal experiment; animal model; antibody response; Article; cohort analysis; controlled study; Dengue virus 2; hydrogen bond; limit of detection; limit of quantitation; mouse; nonhuman; prM E gene; thermostability; virus gene; virus morphology; virus pathogenesis; Zika fever; Zika virus; amino acid substitution; animal; dengue; Dengue virus; disease model; dna mutational analysis; gene deletion; genetic recombination; genetics; immunology; isolation and purification; physiology; radiation response; temperature; virulence; virus replication; Zika Virus Infection; Amino Acid Substitution; Animals; Dengue; Dengue Virus; Disease Models, Animal; DNA Mutational Analysis; Mice; Recombination, Genetic; Sequence Deletion; Temperature; Vaccines, Attenuated; Viral Envelope Proteins; Viral Vaccines; Virulence; Virus Replication; Zika Virus
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/183579
• Institution: National University of Singapore

10.1128/mBio.02134-16