Prohibitin plays a critical role in Enterovirus 71 neuropathogenesis

• Main Authors: Too I.H.K., Bonne I., Tan E.L., Chu J.J.H., Alonso S.
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: Public Library of Science 2020
• Subjects: alpha enolase; antineoplastic agent; asudemotide; immunoglobulin G; mitogen activated protein kinase; peripherin; phosphatidylethanolamine binding protein; prohibitin; protein disulfide isomerase; rocaglamide; small interfering RNA; stomatin; unclassified drug; virus capsid antigen; antivirus agent; benzofuran derivative; nerve protein; repressor protein; animal cell; animal experiment; animal model; Article; bioinformatics; cell proliferation; cell viability assay; chikungunya; controlled study; cytotoxicity; dengue; Enterovirus A71; Enterovirus infection; flow cytometry; gene silencing; genetic transfection; hepatitis C; host pathogen interaction; human; human cell; immunofluorescence; immunohistochemistry; immunoprecipitation; luciferase assay; mass spectrometry; mitochondrial membrane potential; molecular genetics; mouse; neuroblastoma; neuropathology; nonhuman; proteomics; rhabdomyosarcoma; signal transduction; transmission electron microscopy; viral plaque assay; Western blotting; animal; antagonists and inhibitors; cell line; cell membrane; drug effect; Enterovirus A; genetics; germfree animal; knockout mouse; metabolism; mitochondrial membrane; nerve cell; pathogenicity; pathology; physiology; procedures; RNA interference; survival analysis; ultrastructure; virology; virus entry; virus replication; Animals; Antiviral Agents; Benzofurans; Cell Line; Cell Membrane; Enterovirus A, Human; Enterovirus Infections; Host-Pathogen Interactions; Humans; Mice; Mice, Knockout; Microscopy, Electron, Transmission; Mitochondrial Membranes; Nerve Tissue Proteins; Neurons; Proteomics; Repressor Proteins; RNA Interference; Specific Pathogen-Free Organisms; Survival Analysis; Virus Internalization; Virus Replication
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165623
• Institution: National University of Singapore

10.1371/journal.ppat.1006778