Impact of smoking and brain metastasis on outcomes of advanced EGFR mutation lung adenocarcinoma patients treated with first line epidermal growth factor receptor tyrosine kinase inhibitors

10.1371/journal.pone.0123587

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Main Authors:	Jain A., Lim C., Gan E.M., Ng D.Z., Ng Q.S., Ang M.K., Takano A., Chan K.S., Tan W.M., Kanesvaran R., Toh C.K., Loo C.M., Hsu A.A.L., Devanand A., Lim C.H., Koong H.N., Koh T., Fong K.W., Yap S.P., Kim S.W., Chowbay B., Oon L., Lim K.H., Lim W.T., Tan E.H., Tan D.S.W.
Other Authors:	SURGERY
Format:	Article
Published:	Public Library of Science 2020
Subjects:	afatinib erlotinib gefitinib vasculotropin epidermal growth factor receptor protein kinase inhibitor advanced cancer age aged Article Asia brain metastasis cancer palliative therapy cancer staging cancer survival cohort analysis controlled study correlational study disease association EGFR gene female follow up human lung adenocarcinoma major clinical study male overall survival progression free survival retrospective study sex difference smoking treatment outcome adenocarcinoma adult adverse effects antagonists and inhibitors brain tumor demography disease course disease free survival dna mutational analysis drug effects enzymology genetics Kaplan Meier method Lung Neoplasms middle aged multivariate analysis mutation reflex secondary very elderly Adenocarcinoma Adult Aged Aged, 80 and over Brain Neoplasms Cohort Studies Demography Disease Progression Disease-Free Survival DNA Mutational Analysis Female Humans Kaplan-Meier Estimate Male Middle Aged Multivariate Analysis Mutation Neoplasm Staging Protein Kinase Inhibitors Receptor, Epidermal Growth Factor Reflex Smoking Treatment Outcome
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/165697
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1656972024-04-25T02:39:14Z Impact of smoking and brain metastasis on outcomes of advanced EGFR mutation lung adenocarcinoma patients treated with first line epidermal growth factor receptor tyrosine kinase inhibitors Jain A. Lim C. Gan E.M. Ng D.Z. Ng Q.S. Ang M.K. Takano A. Chan K.S. Tan W.M. Kanesvaran R. Toh C.K. Loo C.M. Hsu A.A.L. Devanand A. Lim C.H. Koong H.N. Koh T. Fong K.W. Yap S.P. Kim S.W. Chowbay B. Oon L. Lim K.H. Lim W.T. Tan E.H. Tan D.S.W. SURGERY DUKE-NUS MEDICAL SCHOOL SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH afatinib erlotinib gefitinib vasculotropin epidermal growth factor receptor protein kinase inhibitor advanced cancer age aged Article Asia brain metastasis cancer palliative therapy cancer staging cancer survival cohort analysis controlled study correlational study disease association EGFR gene female follow up human lung adenocarcinoma major clinical study male overall survival progression free survival retrospective study sex difference smoking treatment outcome adenocarcinoma adult adverse effects antagonists and inhibitors brain tumor demography disease course disease free survival dna mutational analysis drug effects enzymology genetics Kaplan Meier method Lung Neoplasms middle aged multivariate analysis mutation reflex secondary smoking treatment outcome very elderly Adenocarcinoma Adult Aged Aged, 80 and over Brain Neoplasms Cohort Studies Demography Disease Progression Disease-Free Survival DNA Mutational Analysis Female Humans Kaplan-Meier Estimate Lung Neoplasms Male Middle Aged Multivariate Analysis Mutation Neoplasm Staging Protein Kinase Inhibitors Receptor, Epidermal Growth Factor Reflex Smoking Treatment Outcome 10.1371/journal.pone.0123587 PLoS ONE 10 5 e0123587 2020-03-19T03:02:03Z 2020-03-19T03:02:03Z 2015 Article Jain A., Lim C., Gan E.M., Ng D.Z., Ng Q.S., Ang M.K., Takano A., Chan K.S., Tan W.M., Kanesvaran R., Toh C.K., Loo C.M., Hsu A.A.L., Devanand A., Lim C.H., Koong H.N., Koh T., Fong K.W., Yap S.P., Kim S.W., Chowbay B., Oon L., Lim K.H., Lim W.T., Tan E.H., Tan D.S.W. (2015). Impact of smoking and brain metastasis on outcomes of advanced EGFR mutation lung adenocarcinoma patients treated with first line epidermal growth factor receptor tyrosine kinase inhibitors. PLoS ONE 10 (5) : e0123587. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0123587 19326203 https://scholarbank.nus.edu.sg/handle/10635/165697 Public Library of Science Unpaywall 20200320
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	afatinib erlotinib gefitinib vasculotropin epidermal growth factor receptor protein kinase inhibitor advanced cancer age aged Article Asia brain metastasis cancer palliative therapy cancer staging cancer survival cohort analysis controlled study correlational study disease association EGFR gene female follow up human lung adenocarcinoma major clinical study male overall survival progression free survival retrospective study sex difference smoking treatment outcome adenocarcinoma adult adverse effects antagonists and inhibitors brain tumor demography disease course disease free survival dna mutational analysis drug effects enzymology genetics Kaplan Meier method Lung Neoplasms middle aged multivariate analysis mutation reflex secondary smoking treatment outcome very elderly Adenocarcinoma Adult Aged Aged, 80 and over Brain Neoplasms Cohort Studies Demography Disease Progression Disease-Free Survival DNA Mutational Analysis Female Humans Kaplan-Meier Estimate Lung Neoplasms Male Middle Aged Multivariate Analysis Mutation Neoplasm Staging Protein Kinase Inhibitors Receptor, Epidermal Growth Factor Reflex Smoking Treatment Outcome
spellingShingle	afatinib erlotinib gefitinib vasculotropin epidermal growth factor receptor protein kinase inhibitor advanced cancer age aged Article Asia brain metastasis cancer palliative therapy cancer staging cancer survival cohort analysis controlled study correlational study disease association EGFR gene female follow up human lung adenocarcinoma major clinical study male overall survival progression free survival retrospective study sex difference smoking treatment outcome adenocarcinoma adult adverse effects antagonists and inhibitors brain tumor demography disease course disease free survival dna mutational analysis drug effects enzymology genetics Kaplan Meier method Lung Neoplasms middle aged multivariate analysis mutation reflex secondary smoking treatment outcome very elderly Adenocarcinoma Adult Aged Aged, 80 and over Brain Neoplasms Cohort Studies Demography Disease Progression Disease-Free Survival DNA Mutational Analysis Female Humans Kaplan-Meier Estimate Lung Neoplasms Male Middle Aged Multivariate Analysis Mutation Neoplasm Staging Protein Kinase Inhibitors Receptor, Epidermal Growth Factor Reflex Smoking Treatment Outcome Jain A. Lim C. Gan E.M. Ng D.Z. Ng Q.S. Ang M.K. Takano A. Chan K.S. Tan W.M. Kanesvaran R. Toh C.K. Loo C.M. Hsu A.A.L. Devanand A. Lim C.H. Koong H.N. Koh T. Fong K.W. Yap S.P. Kim S.W. Chowbay B. Oon L. Lim K.H. Lim W.T. Tan E.H. Tan D.S.W. Impact of smoking and brain metastasis on outcomes of advanced EGFR mutation lung adenocarcinoma patients treated with first line epidermal growth factor receptor tyrosine kinase inhibitors
description	10.1371/journal.pone.0123587
author2	SURGERY
author_facet	SURGERY Jain A. Lim C. Gan E.M. Ng D.Z. Ng Q.S. Ang M.K. Takano A. Chan K.S. Tan W.M. Kanesvaran R. Toh C.K. Loo C.M. Hsu A.A.L. Devanand A. Lim C.H. Koong H.N. Koh T. Fong K.W. Yap S.P. Kim S.W. Chowbay B. Oon L. Lim K.H. Lim W.T. Tan E.H. Tan D.S.W.
format	Article
author	Jain A. Lim C. Gan E.M. Ng D.Z. Ng Q.S. Ang M.K. Takano A. Chan K.S. Tan W.M. Kanesvaran R. Toh C.K. Loo C.M. Hsu A.A.L. Devanand A. Lim C.H. Koong H.N. Koh T. Fong K.W. Yap S.P. Kim S.W. Chowbay B. Oon L. Lim K.H. Lim W.T. Tan E.H. Tan D.S.W.
author_sort	Jain A.
title	Impact of smoking and brain metastasis on outcomes of advanced EGFR mutation lung adenocarcinoma patients treated with first line epidermal growth factor receptor tyrosine kinase inhibitors
title_short	Impact of smoking and brain metastasis on outcomes of advanced EGFR mutation lung adenocarcinoma patients treated with first line epidermal growth factor receptor tyrosine kinase inhibitors
title_full	Impact of smoking and brain metastasis on outcomes of advanced EGFR mutation lung adenocarcinoma patients treated with first line epidermal growth factor receptor tyrosine kinase inhibitors
title_fullStr	Impact of smoking and brain metastasis on outcomes of advanced EGFR mutation lung adenocarcinoma patients treated with first line epidermal growth factor receptor tyrosine kinase inhibitors
title_full_unstemmed	Impact of smoking and brain metastasis on outcomes of advanced EGFR mutation lung adenocarcinoma patients treated with first line epidermal growth factor receptor tyrosine kinase inhibitors
title_sort	impact of smoking and brain metastasis on outcomes of advanced egfr mutation lung adenocarcinoma patients treated with first line epidermal growth factor receptor tyrosine kinase inhibitors
publisher	Public Library of Science
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/165697
_version_	1800913927045906432

Impact of smoking and brain metastasis on outcomes of advanced EGFR mutation lung adenocarcinoma patients treated with first line epidermal growth factor receptor tyrosine kinase inhibitors

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