Reduction of tendon adhesions following administration of adaprev, a hypertonic solution of mannose-6-phosphate: Mechanism of action studies

10.1371/journal.pone.0112672

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Main Authors:	Wong J.K.F., Metcalfe A.D., Wong R., Bush J., Platt C., Garcon A., Goldspink N., McGrouther D.A., Ferguson M.W.J.
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	Public Library of Science 2020
Subjects:	adaprev collagen type 1 heat shock protein 47 hypertonic solution Smad2 protein Smad3 protein somatomedin B receptor synaptophysin transforming growth factor beta receptor 1 unclassified drug collagen mannose phosphate mannose-6-phosphate transforming growth factor beta actin filament adhesion adult animal cell animal experiment animal model animal tissue Article cell migration cell proliferation cell stress cell viability collagen synthesis concentration response controlled study cytotoxicity drug bioavailability ex vivo study fibroblast hyperosmotic stress in vitro study in vivo study male mouse nonhuman osmolality protein phosphorylation signal transduction tendon fibroblast tendon injury tensile strength animal biomechanics cell culture disease model drug effects human metabolism pathophysiology rabbit Tendon Injuries Tissue Adhesions wound healing Animals Biomechanical Phenomena Cell Proliferation Cells, Cultured Collagen Disease Models, Animal Humans Hypertonic Solutions Mannosephosphates Mice Rabbits Signal Transduction Tensile Strength Transforming Growth Factor beta Wound Healing
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/165707
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1657072023-10-31T08:37:40Z Reduction of tendon adhesions following administration of adaprev, a hypertonic solution of mannose-6-phosphate: Mechanism of action studies Wong J.K.F. Metcalfe A.D. Wong R. Bush J. Platt C. Garcon A. Goldspink N. McGrouther D.A. Ferguson M.W.J. DUKE-NUS MEDICAL SCHOOL adaprev collagen type 1 heat shock protein 47 hypertonic solution Smad2 protein Smad3 protein somatomedin B receptor synaptophysin transforming growth factor beta receptor 1 unclassified drug collagen hypertonic solution mannose phosphate mannose-6-phosphate transforming growth factor beta actin filament adhesion adult animal cell animal experiment animal model animal tissue Article cell migration cell proliferation cell stress cell viability collagen synthesis concentration response controlled study cytotoxicity drug bioavailability ex vivo study fibroblast hyperosmotic stress in vitro study in vivo study male mouse nonhuman osmolality protein phosphorylation signal transduction tendon fibroblast tendon injury tensile strength animal biomechanics cell culture disease model drug effects human metabolism pathophysiology rabbit Tendon Injuries Tissue Adhesions wound healing Animals Biomechanical Phenomena Cell Proliferation Cells, Cultured Collagen Disease Models, Animal Humans Hypertonic Solutions Mannosephosphates Mice Rabbits Signal Transduction Tendon Injuries Tensile Strength Tissue Adhesions Transforming Growth Factor beta Wound Healing 10.1371/journal.pone.0112672 PLoS ONE 9 11 e112672 2020-03-19T03:03:42Z 2020-03-19T03:03:42Z 2014 Article Wong J.K.F., Metcalfe A.D., Wong R., Bush J., Platt C., Garcon A., Goldspink N., McGrouther D.A., Ferguson M.W.J. (2014). Reduction of tendon adhesions following administration of adaprev, a hypertonic solution of mannose-6-phosphate: Mechanism of action studies. PLoS ONE 9 (11) : e112672. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0112672 19326203 https://scholarbank.nus.edu.sg/handle/10635/165707 Public Library of Science Unpaywall 20200320
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	adaprev collagen type 1 heat shock protein 47 hypertonic solution Smad2 protein Smad3 protein somatomedin B receptor synaptophysin transforming growth factor beta receptor 1 unclassified drug collagen hypertonic solution mannose phosphate mannose-6-phosphate transforming growth factor beta actin filament adhesion adult animal cell animal experiment animal model animal tissue Article cell migration cell proliferation cell stress cell viability collagen synthesis concentration response controlled study cytotoxicity drug bioavailability ex vivo study fibroblast hyperosmotic stress in vitro study in vivo study male mouse nonhuman osmolality protein phosphorylation signal transduction tendon fibroblast tendon injury tensile strength animal biomechanics cell culture disease model drug effects human metabolism pathophysiology rabbit Tendon Injuries Tissue Adhesions wound healing Animals Biomechanical Phenomena Cell Proliferation Cells, Cultured Collagen Disease Models, Animal Humans Hypertonic Solutions Mannosephosphates Mice Rabbits Signal Transduction Tendon Injuries Tensile Strength Tissue Adhesions Transforming Growth Factor beta Wound Healing
spellingShingle	adaprev collagen type 1 heat shock protein 47 hypertonic solution Smad2 protein Smad3 protein somatomedin B receptor synaptophysin transforming growth factor beta receptor 1 unclassified drug collagen hypertonic solution mannose phosphate mannose-6-phosphate transforming growth factor beta actin filament adhesion adult animal cell animal experiment animal model animal tissue Article cell migration cell proliferation cell stress cell viability collagen synthesis concentration response controlled study cytotoxicity drug bioavailability ex vivo study fibroblast hyperosmotic stress in vitro study in vivo study male mouse nonhuman osmolality protein phosphorylation signal transduction tendon fibroblast tendon injury tensile strength animal biomechanics cell culture disease model drug effects human metabolism pathophysiology rabbit Tendon Injuries Tissue Adhesions wound healing Animals Biomechanical Phenomena Cell Proliferation Cells, Cultured Collagen Disease Models, Animal Humans Hypertonic Solutions Mannosephosphates Mice Rabbits Signal Transduction Tendon Injuries Tensile Strength Tissue Adhesions Transforming Growth Factor beta Wound Healing Wong J.K.F. Metcalfe A.D. Wong R. Bush J. Platt C. Garcon A. Goldspink N. McGrouther D.A. Ferguson M.W.J. Reduction of tendon adhesions following administration of adaprev, a hypertonic solution of mannose-6-phosphate: Mechanism of action studies
description	10.1371/journal.pone.0112672
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Wong J.K.F. Metcalfe A.D. Wong R. Bush J. Platt C. Garcon A. Goldspink N. McGrouther D.A. Ferguson M.W.J.
format	Article
author	Wong J.K.F. Metcalfe A.D. Wong R. Bush J. Platt C. Garcon A. Goldspink N. McGrouther D.A. Ferguson M.W.J.
author_sort	Wong J.K.F.
title	Reduction of tendon adhesions following administration of adaprev, a hypertonic solution of mannose-6-phosphate: Mechanism of action studies
title_short	Reduction of tendon adhesions following administration of adaprev, a hypertonic solution of mannose-6-phosphate: Mechanism of action studies
title_full	Reduction of tendon adhesions following administration of adaprev, a hypertonic solution of mannose-6-phosphate: Mechanism of action studies
title_fullStr	Reduction of tendon adhesions following administration of adaprev, a hypertonic solution of mannose-6-phosphate: Mechanism of action studies
title_full_unstemmed	Reduction of tendon adhesions following administration of adaprev, a hypertonic solution of mannose-6-phosphate: Mechanism of action studies
title_sort	reduction of tendon adhesions following administration of adaprev, a hypertonic solution of mannose-6-phosphate: mechanism of action studies
publisher	Public Library of Science
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/165707
_version_	1781791960056463360

Reduction of tendon adhesions following administration of adaprev, a hypertonic solution of mannose-6-phosphate: Mechanism of action studies

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