Reduction of tendon adhesions following administration of adaprev, a hypertonic solution of mannose-6-phosphate: Mechanism of action studies

• Main Authors: Wong J.K.F., Metcalfe A.D., Wong R., Bush J., Platt C., Garcon A., Goldspink N., McGrouther D.A., Ferguson M.W.J.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Public Library of Science 2020
• Subjects: adaprev; collagen type 1; heat shock protein 47; hypertonic solution; Smad2 protein; Smad3 protein; somatomedin B receptor; synaptophysin; transforming growth factor beta receptor 1; unclassified drug; collagen; mannose phosphate; mannose-6-phosphate; transforming growth factor beta; actin filament; adhesion; adult; animal cell; animal experiment; animal model; animal tissue; Article; cell migration; cell proliferation; cell stress; cell viability; collagen synthesis; concentration response; controlled study; cytotoxicity; drug bioavailability; ex vivo study; fibroblast; hyperosmotic stress; in vitro study; in vivo study; male; mouse; nonhuman; osmolality; protein phosphorylation; signal transduction; tendon fibroblast; tendon injury; tensile strength; animal; biomechanics; cell culture; disease model; drug effects; human; metabolism; pathophysiology; rabbit; Tendon Injuries; Tissue Adhesions; wound healing; Animals; Biomechanical Phenomena; Cell Proliferation; Cells, Cultured; Collagen; Disease Models, Animal; Humans; Hypertonic Solutions; Mannosephosphates; Mice; Rabbits; Signal Transduction; Tensile Strength; Transforming Growth Factor beta; Wound Healing
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165707
• Institution: National University of Singapore

10.1371/journal.pone.0112672