ITF2357 transactivates Id3 and regulate TGF?/BMP7 signaling pathways to attenuate corneal fibrosis

• Main Authors: Lim, R.R, Tan, A, Liu, Y.-C, Barathi, V.A, Mohan, R.R, Mehta, J.S, Chaurasia, S.S
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: collagen type 1; collagen type 4; fibronectin; givinostat hydrochloride; histone deacetylase inhibitor; hydroxamic acid; inhibitor of differentiation protein; osteogenic protein 1; procollagen proline 2 oxoglutarate 4 dioxygenase; Smad protein; transforming growth factor beta; vitronectin receptor; adverse effects; animal; antagonists and inhibitors; cornea stroma; disease model; drug effects; fibroblast; fibrosis; gene expression regulation; genetics; human; metabolism; pathology; phosphorylation; photorefractive keratectomy; primary cell culture; rabbits and hares; signal transduction; Animals; Bone Morphogenetic Protein 7; Collagen Type I; Collagen Type IV; Corneal Stroma; Disease Models, Animal; Fibroblasts; Fibronectins; Fibrosis; Gene Expression Regulation; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Inhibitor of Differentiation Proteins; Integrin alphaVbeta3; Phosphorylation; Photorefractive Keratectomy; Primary Cell Culture; Procollagen-Proline Dioxygenase; Rabbits; Signal Transduction; Smad Proteins; Transforming Growth Factor beta
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/182505
• Institution: National University of Singapore

10.1038/srep20841