Cycloheximide can induce bax/bak dependent myeloid cell death independently of multiple BH3-only proteins

• Main Authors: Goodall K.J., Finch-Edmondson M.L., Van Vuuren J., Yeoh G.C., Gentle I.E., Vince J.E., Ekert P.G., Vaux D.L., Callus B.A.
• Other Authors: MECHANOBIOLOGY INSTITUTE
• Format: Article
• Published: Public Library of Science 2020
• Subjects: BH3 protein; complementary DNA; cycloheximide; protein Bak; protein Bax; protein mcl 1; roscovitine; apoptosis regulatory protein; proteasome; protein bcl 2; protein synthesis inhibitor; animal cell; animal cell culture; apoptosis; Article; bone marrow cell; cell viability; controlled study; cytolysis; immunoblotting; mouse; nonhuman; plasmid; protein depletion; protein expression; animal; cell death; cell line; dose response; drug effects; gene inactivation; genetics; human; metabolism; Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Cell Death; Cell Line; Cycloheximide; Dose-Response Relationship, Drug; Gene Knockout Techniques; Humans; Mice; Myeloid Cells; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-bcl-2
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165735
• Institution: National University of Singapore

10.1371/journal.pone.0164003