Hepatitis C virus mediated chronic inflammation and tumorigenesis in the humanised immune system and liver mouse model

• Main Authors: Zheng Z., Sze C.W., Keng C.T., Al-Haddawi M., Liu M., Tan S.Y., Kwek H.L., Her Z., Chan X.Y., Barnwal B., Loh E., Chang K.T.E., Tan T.C., Tan Y.-J., Chen Q.
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: Public Library of Science 2020
• Subjects: gamma interferon; interleukin 10; interleukin 12p70; interleukin 17; interleukin 18; interleukin 23; interleukin 6; interleukin 8; monocyte chemotactic protein 1; virus RNA; biological marker; CD68 antigen, human; cytokine; differentiation antigen; leukocyte antigen; serum albumin; animal experiment; animal model; Article; clinical feature; controlled study; disease association; disease model; granulomatosis; hepatitis C; Hepatitis C virus; human; human tissue; immune response; immune system; immunocompetent cell; incidence; liver adenoma; liver carcinogenesis; liver cell carcinoma; liver fibrosis; macrophage; monocyte; mouse; nonhuman; pathogenesis; phenotype; RNA analysis; T lymphocyte; viremia; animal; blood; Carcinoma, Hepatocellular; cell transformation; chronic hepatitis C; complication; Hepacivirus; immunology; liver function test; Liver Neoplasms; metabolism; pathology; T lymphocyte subpopulation; virology; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Biomarkers; Cell Transformation, Neoplastic; Cytokines; Disease Models, Animal; Hepatitis C, Chronic; Liver Function Tests; Macrophages; Mice; Monocytes; Serum Albumin; T-Lymphocyte Subsets; Viremia
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165778
• Institution: National University of Singapore

10.1371/journal.pone.0184127