Regulation of the NRF2 transcription factor by andrographolide and organic extracts from plant endophytes

• Main Authors: Wen Wong D.P., Ng M.Y., Leung J.Y., Boh B.K., Lim E.C., Tan S.H., Lim S., Seah W.H., Hu C.Z., Ho B.C., Ng D.H.P., Hagen T.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Public Library of Science 2020
• Subjects: andrographolide; cullin; cullin 3; kelch like ECH associated protein 1; protein RBX1; RING finger protein; sulforaphane; transcription factor Nrf2; unclassified drug; carrier protein; CUL3 protein, human; diterpene; KEAP1 protein, human; NFE2L2 protein, human; plant extract; protein binding; RBX1 protein, human; Article; binding affinity; Calymperes erosum; Campylopus serratus; densitometry; Dicranopteris linearis; endophyte; enzyme activity; fern; human; human cell; moss; nonhuman; Ophioglossum reticulatum; Philonotis thwaitesii; Phlegmariurus phlegmaria; protein degradation; protein expression; protein function; protein interaction; protein localization; protein processing; protein stability; Psilotum nudum; Pyrrosia piloselloides; Taenitis blechnoides; ubiquitination; Vesicularia dubyana; binding site; chemistry; drug effect; gene expression regulation; HEK293 cell line; metabolism; secondary metabolism; Binding Sites; Bryophyta; Carrier Proteins; Cullin Proteins; Diterpenes; Endophytes; Ferns; Gene Expression Regulation; HEK293 Cells; Humans; Kelch-Like ECH-Associated Protein 1; NF-E2-Related Factor 2; Plant Extracts; Protein Binding; Secondary Metabolism; Ubiquitination
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165895
• Institution: National University of Singapore

10.1371/journal.pone.0204853