Truncations of the titin Z-disc predispose to a heart failure with preserved ejection phenotype in the context of pressure overload

• Main Authors: Ye L., Su L., Wang C., Loo S., Tee G., Tan S., Khin S.W., Ko S., Su B., Cook S.A.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Public Library of Science 2020
• Subjects: collagen; connectin; isoprotein; Ttn protein, rat; animal experiment; animal model; animal tissue; aortic constriction; apoptosis; Article; capillary rarefaction; cardiac muscle cell; controlled study; diastolic blood pressure; disease predisposition; heart failure with preserved ejection fraction; heart left ventricle function; heart left ventricle mass; heart left ventricle overload; heart muscle fibrosis; heterozygosity; histology; male; nonhuman; phenotype; pressure volume curve; rat; rat model; systolic blood pressure; transthoracic echocardiography; animal; aortic valve stenosis; chemistry; complication; fibrosis; Fischer 344 rat; genetic polymorphism; genetic predisposition; genetics; heart failure; hypertension; pathophysiology; physiology; protein domain; transgenic rat; Animals; Aortic Valve Stenosis; Connectin; Fibrosis; Genetic Predisposition to Disease; Heart Failure; Hypertension; Male; Phenotype; Polymorphism, Genetic; Protein Interaction Domains and Motifs; Protein Isoforms; Rats; Rats, Inbred F344; Rats, Transgenic; Ventricular Dysfunction, Left; Ventricular Function, Left
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165899
• Institution: National University of Singapore

10.1371/journal.pone.0201498