Truncations of the titin Z-disc predispose to a heart failure with preserved ejection phenotype in the context of pressure overload

10.1371/journal.pone.0201498

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Main Authors:	Ye L., Su L., Wang C., Loo S., Tee G., Tan S., Khin S.W., Ko S., Su B., Cook S.A.
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	Public Library of Science 2020
Subjects:	collagen connectin isoprotein Ttn protein, rat animal experiment animal model animal tissue aortic constriction apoptosis Article capillary rarefaction cardiac muscle cell controlled study diastolic blood pressure disease predisposition heart failure with preserved ejection fraction heart left ventricle function heart left ventricle mass heart left ventricle overload heart muscle fibrosis heterozygosity histology male nonhuman phenotype pressure volume curve rat rat model systolic blood pressure transthoracic echocardiography animal aortic valve stenosis chemistry complication fibrosis Fischer 344 rat genetic polymorphism genetic predisposition genetics heart failure hypertension pathophysiology physiology protein domain transgenic rat Animals Aortic Valve Stenosis Connectin Fibrosis Genetic Predisposition to Disease Heart Failure Hypertension Male Phenotype Polymorphism, Genetic Protein Interaction Domains and Motifs Protein Isoforms Rats Rats, Inbred F344 Rats, Transgenic Ventricular Dysfunction, Left Ventricular Function, Left
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/165899
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1658992024-11-14T02:18:16Z Truncations of the titin Z-disc predispose to a heart failure with preserved ejection phenotype in the context of pressure overload Ye L. Su L. Wang C. Loo S. Tee G. Tan S. Khin S.W. Ko S. Su B. Cook S.A. DUKE-NUS MEDICAL SCHOOL collagen connectin connectin isoprotein Ttn protein, rat animal experiment animal model animal tissue aortic constriction apoptosis Article capillary rarefaction cardiac muscle cell controlled study diastolic blood pressure disease predisposition heart failure with preserved ejection fraction heart left ventricle function heart left ventricle mass heart left ventricle overload heart muscle fibrosis heterozygosity histology male nonhuman phenotype pressure volume curve rat rat model systolic blood pressure transthoracic echocardiography animal aortic valve stenosis chemistry complication fibrosis Fischer 344 rat genetic polymorphism genetic predisposition genetics heart failure hypertension pathophysiology phenotype physiology protein domain transgenic rat Animals Aortic Valve Stenosis Connectin Fibrosis Genetic Predisposition to Disease Heart Failure Hypertension Male Phenotype Polymorphism, Genetic Protein Interaction Domains and Motifs Protein Isoforms Rats Rats, Inbred F344 Rats, Transgenic Ventricular Dysfunction, Left Ventricular Function, Left 10.1371/journal.pone.0201498 PLoS ONE 13 7 e0201498 2020-03-23T06:19:58Z 2020-03-23T06:19:58Z 2018 Article Ye L., Su L., Wang C., Loo S., Tee G., Tan S., Khin S.W., Ko S., Su B., Cook S.A. (2018). Truncations of the titin Z-disc predispose to a heart failure with preserved ejection phenotype in the context of pressure overload. PLoS ONE 13 (7) : e0201498. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0201498 19326203 https://scholarbank.nus.edu.sg/handle/10635/165899 Public Library of Science Unpaywall 20200320
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	collagen connectin connectin isoprotein Ttn protein, rat animal experiment animal model animal tissue aortic constriction apoptosis Article capillary rarefaction cardiac muscle cell controlled study diastolic blood pressure disease predisposition heart failure with preserved ejection fraction heart left ventricle function heart left ventricle mass heart left ventricle overload heart muscle fibrosis heterozygosity histology male nonhuman phenotype pressure volume curve rat rat model systolic blood pressure transthoracic echocardiography animal aortic valve stenosis chemistry complication fibrosis Fischer 344 rat genetic polymorphism genetic predisposition genetics heart failure hypertension pathophysiology phenotype physiology protein domain transgenic rat Animals Aortic Valve Stenosis Connectin Fibrosis Genetic Predisposition to Disease Heart Failure Hypertension Male Phenotype Polymorphism, Genetic Protein Interaction Domains and Motifs Protein Isoforms Rats Rats, Inbred F344 Rats, Transgenic Ventricular Dysfunction, Left Ventricular Function, Left
spellingShingle	collagen connectin connectin isoprotein Ttn protein, rat animal experiment animal model animal tissue aortic constriction apoptosis Article capillary rarefaction cardiac muscle cell controlled study diastolic blood pressure disease predisposition heart failure with preserved ejection fraction heart left ventricle function heart left ventricle mass heart left ventricle overload heart muscle fibrosis heterozygosity histology male nonhuman phenotype pressure volume curve rat rat model systolic blood pressure transthoracic echocardiography animal aortic valve stenosis chemistry complication fibrosis Fischer 344 rat genetic polymorphism genetic predisposition genetics heart failure hypertension pathophysiology phenotype physiology protein domain transgenic rat Animals Aortic Valve Stenosis Connectin Fibrosis Genetic Predisposition to Disease Heart Failure Hypertension Male Phenotype Polymorphism, Genetic Protein Interaction Domains and Motifs Protein Isoforms Rats Rats, Inbred F344 Rats, Transgenic Ventricular Dysfunction, Left Ventricular Function, Left Ye L. Su L. Wang C. Loo S. Tee G. Tan S. Khin S.W. Ko S. Su B. Cook S.A. Truncations of the titin Z-disc predispose to a heart failure with preserved ejection phenotype in the context of pressure overload
description	10.1371/journal.pone.0201498
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Ye L. Su L. Wang C. Loo S. Tee G. Tan S. Khin S.W. Ko S. Su B. Cook S.A.
format	Article
author	Ye L. Su L. Wang C. Loo S. Tee G. Tan S. Khin S.W. Ko S. Su B. Cook S.A.
author_sort	Ye L.
title	Truncations of the titin Z-disc predispose to a heart failure with preserved ejection phenotype in the context of pressure overload
title_short	Truncations of the titin Z-disc predispose to a heart failure with preserved ejection phenotype in the context of pressure overload
title_full	Truncations of the titin Z-disc predispose to a heart failure with preserved ejection phenotype in the context of pressure overload
title_fullStr	Truncations of the titin Z-disc predispose to a heart failure with preserved ejection phenotype in the context of pressure overload
title_full_unstemmed	Truncations of the titin Z-disc predispose to a heart failure with preserved ejection phenotype in the context of pressure overload
title_sort	truncations of the titin z-disc predispose to a heart failure with preserved ejection phenotype in the context of pressure overload
publisher	Public Library of Science
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/165899
_version_	1821203014289981440

Truncations of the titin Z-disc predispose to a heart failure with preserved ejection phenotype in the context of pressure overload

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