Steroid resistance in COPD? overlap and differential anti-inflammatory effects in smokers and ex-smokers

• Main Authors: Hoonhorst S.J.M., Ten Hacken N.H.T., Vonk J.M., Timens W., Hiemstra P.S., Lapperre T.S., Sterk P.J., Postma D.S.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Public Library of Science 2020
• Subjects: corticosteroid; fluticasone propionate; placebo; salmeterol; adult; aged; antiinflammatory activity; article; bronchus biopsy; CD3+ T lymphocyte; CD4+ T lymphocyte; CD8+ T lymphocyte; chronic obstructive lung disease; clinical trial (topic); comparative study; controlled study; correlational study; ex smoker; female; human; human cell; human tissue; inflammatory cell; long term care; lung function; lymphocyte; major clinical study; male; mast cell; named groups of persons; neutrophil; outcomes research; post hoc analysis; respiratory tract allergy; short course therapy; smoking; sputum culture; treatment duration; Adrenal Cortex Hormones; Aged; Drug Resistance; Female; Humans; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Smoking; Smoking Cessation; Time Factors
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165960
• Institution: National University of Singapore

10.1371/journal.pone.0087443