Inhaled Steroids Modulate Extracellular Matrix Composition in Bronchial Biopsies of COPD Patients: A Randomized, Controlled Trial

• Main Authors: Kunz L.I.Z., Strebus J., Budulac S.E., Lapperre T.S., Sterk P.J., Postma D.S., Mauad T., Timens W., Hiemstra P.S.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Public Library of Science 2020
• Subjects: collagen type 1; collagen type 3; corticosteroid derivative; decorin; fluticasone; fluticasone plus salmeterol; fluticasone propionate; glucocorticoid; placebo; unclassified drug; versican; adult; aged; airway remodeling; article; bronchus biopsy; chronic obstructive lung disease; controlled study; correlational study; disease severity; drug efficacy; elastic fiber; extracellular matrix; female; forced expiratory volume; human; human tissue; image analysis; immunohistochemistry; long term care; lung function; major clinical study; male; randomized controlled trial; smoking; Administration, Inhalation; Adult; Androstadienes; Biopsy; Bronchi; Collagen Type I; Extracellular Matrix; Extracellular Matrix Proteins; Female; Forced Expiratory Volume; Humans; Immunohistochemistry; Male; Middle Aged; Placebos; Pulmonary Disease, Chronic Obstructive; Smoking; Steroids
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/166198
• Institution: National University of Singapore

10.1371/journal.pone.0063430